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Generation of Human Cell Lines with Inactivated GLUT1 Genes

TITLEGeneration of Human Cell Lines with Inactivated GLUT1 GenesCASE NUMBERC11819INVENTION NOVELTYTangible material involving generation of mutant isogenic, cancerous cell lines RKO and DLD1 disrupted alleles for GLUT1 protein by homologous recombination. VALUE PROPOSITIONThis tangible material can serve as an important research tool for studying the...

Published: 9/26/2024 | Inventor(s): Kenneth Kinzler, Jihye Yun, Nickolas Papadopoulos, Bert Vogelstein

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

MEK KO Lines for Drug Discovery

C04918: MEK KO Lines for Drug Discovery Technical Details: MEK knockout in human colorectal cancer cell line HCT116. Looking for Partners: MAP kinase/ERK kinase (MEK) is the specific activator of extracellular signal-regulated kinase (ERK) and is part of a signaling pathway with a pivotal role in the control of cellular proliferation. The cell...

Published: 9/26/2024 | Inventor(s): Nickolas Papadopoulos, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein, Jihye Yun

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

RAS KO Lines for Drug Discovery

C04733: RAS KO Lines for Drug Discovery Technical Details: RAS gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Parsons et al., 2005 Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target the RAS pathway in human cancer cells...

Published: 9/26/2024 | Inventor(s): Kenneth Kinzler, Victor Velculescu, Christoph Lengauer, Jihye Yun, Ray Pagliarini, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

RAF KO Lines for Drug Discovery

C04654: RAF KO Lines for Drug Discovery Technical Details: BRAF kinase gene knockouts of human cancer cell lines.Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target the RAF pathway in human cancer cells or to confirm the specificity of drugs discovered through other approaches. Such...

Published: 9/26/2024 | Inventor(s): Harith Rajagopalan, Christoph Lengauer, Victor Velculescu, Jihye Yun, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools