Search Results - christoph+lengauer

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C04918: MEK KO Lines for Drug Discovery Technical Details: MEK knockout in human colorectal cancer cell line HCT116. Looking for Partners: MAP kinase/ERK kinase (MEK) is the specific activator of extracellular signal-regulated kinase (ERK) and is part of a signaling pathway with a pivotal role in the control of cellular proliferation. The cell...

Published: 6/27/2024 | Inventor(s): Nickolas Papadopoulos, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein, Jihye Yun

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

RAS KO Lines for Drug Discovery

C04733: RAS KO Lines for Drug Discovery Technical Details: RAS gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Parsons et al., 2005 Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target the RAS pathway in human cancer cells...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Victor Velculescu, Christoph Lengauer, Jihye Yun, Ray Pagliarini, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Mutational Analysis of the Serine-threonine Kinome in Colorectal Cancers

C04724: Mutational Analysis of the Serine-threonine Kinome in Colorectal Cancers Technical Details: The invention describes novel mutations in serine-threonine kinase genes within the Phosphatidylinositol-3-OH Kinase (PI(3)K) pathway in patients with colorectal cancer. Details are described in the paper by Parsons et al., 2005 (see below). Looking...

Published: 6/27/2024 | Inventor(s): Alberto Bardelli, Christoph Lengauer, Yardena Samuels, Donald Parsons, Tian-Li Wang, Kenneth Kinzler, Victor Velculescu, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

HAUSP KO Lines for Drug Discovery

C04658: HAUSP KO Lines for Drug Discovery Technical Details: HAUSP (also known as USP7) deubiquitinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Cummins et al., 2004a (see below) Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules...

Published: 6/27/2024 | Inventor(s): Jordan Cummins, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Assay, Cancers, Cell Lines, Clinical Diagnostics, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Human Cell Lines, In Vitro Diagnostics, In Vitro Research Tool, Translational Research Biomarker

RAF KO Lines for Drug Discovery

C04654: RAF KO Lines for Drug Discovery Technical Details: BRAF kinase gene knockouts of human cancer cell lines.Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target the RAF pathway in human cancer cells or to confirm the specificity of drugs discovered through other approaches. Such...

Published: 6/27/2024 | Inventor(s): Harith Rajagopalan, Christoph Lengauer, Victor Velculescu, Jihye Yun, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

PIK3CA KO Lines for Drug Discovery

C04652: PIK3CA KO Lines for Drug Discovery Technical Details: PIK3CA knockouts in human colorectal cancer cell lines HCT116 and DLD1. Details are described in the paper by Samuels et al., 2005 Looking for Partners: JHU scientists have recently discovered that mutations in PIK3CA occur in a significant fraction of cancers. Knockout lines indicated...

Published: 6/27/2024 | Inventor(s): Victor Velculescu, Yardena Samuels, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

SMAC KO Lines for Drug Discovery

C04651: SMAC KO Lines for Drug Discovery Technical Details: Second mitochondrial-derived activator of caspase (SMAC; also known as Diablo) gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Kohli et al., 2004 Looking for Partners: The cell lines described in this invention can be used in...

Published: 6/27/2024 | Inventor(s): Manu Kohli, Lin Zhang, Kenneth Kinzler, Christoph Lengauer, Jian Yu, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Human Cancer Cell Lines Deficient in the CDC4 Gene

C04300: Human Cancer Cell Lines Deficient in the CDC4 Gene Technical Details: To assess the role of CDC4 in genetic instability, we generated cells that lack functional CDC4 genes. An abnormal chromosome number (aneuploidy) is a hallmark of human cancer, recognized for nearly a century. However, the mechanism(s) responsible for aneuploidy has remained...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Harith Rajagopalan, Christoph Lengauer, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Human Cancer Cell Line Deficient in the BLM Gene

C04297: Human Cancer Cell Line Deficient in the BLM Gene Technical Details: To assess the role of BLM in genetic instability, we generated cells that lack functional BLM genes. Genetic instability appears to be required for a normal colorectal epithelial cell to evolve into a cancerous one. Bloom syndrome patients have a strong predisposition to cancer...

Published: 6/27/2024 | Inventor(s): Carlo Traverso, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Carcinogen-specific Induction of Genetic Instability

C03921: Carcinogen-specific Induction of Genetic Instability Technical Details: The researchers created two H3 colorectal cancer cell lines. One cell line has chromosomal instability (CIN) and resistance to 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP). The other cell line has microsatelite instability (MIN) and resistance to methylating...

Published: 6/27/2024 | Inventor(s): Alberto Bardelli, Kenneth Kinzler, Christoph Lengauer, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Gastric Cancer, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

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