Search Results - jian+yu

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C04651: SMAC KO Lines for Drug Discovery Technical Details: Second mitochondrial-derived activator of caspase (SMAC; also known as Diablo) gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Kohli et al., 2004 Looking for Partners: The cell lines described in this invention can be used in...

Published: 6/27/2024 | Inventor(s): Manu Kohli, Lin Zhang, Kenneth Kinzler, Christoph Lengauer, Jian Yu, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

A Cell Line with Targeted Deletions of both Bax and p21

C04312: A Cell Line with Targeted Deletions of both Bax and p21 Technical Details: A Bax and p21 knock out cell line in human colorectal cancer cells. Details are described in the papers by Zhang et al. (2000) and Yu et al. (2003). Looking for Partners: Cells that lack both a functional BAX and p21 gene are relatively resistant to apoptosis....

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Lin Zhang, Jian Yu, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

PUMA Mediates the Apoptotic Response to p53

C04140: PUMA Mediates the Apoptotic Response to p53 Technical Details: The p53 pathway is inactivated in the great majority of human cancers. Of the many physiologic effects of p53 that have been described, current evidence suggests that apoptosis is critical for its tumor suppressor activities. Although several genes that might mediate p53-induced...

Published: 6/27/2024 | Inventor(s): Lin Zhang, Kenneth Kinzler, Bert Vogelstein, Jian Yu

Keywords(s): Biologics, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Gene Therapy, In Vitro Research Tool, Nucleic Acid, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Cell Lines