Search Results - lin+zhang

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Generation of Leucine Rich Repeat Kinase-2 (LRRK2) Knockout Mice

C10385: Generation of Leucine Rich Repeat Kinase-2 (LRRK2) Knockout Mice Value Proposition: In order to understand the normal function of LRRK2, JHU faculty have generated a targeted mutation in the murine homolog of LRRK2. LRRK2 mice are viable, fertile and show no gross pathologic abnormalities.There are no significant difference in body weight,...

Published: 6/27/2024 | Inventor(s): Li Zhang, Valina Dawson, Masayuki Sasaki, Ted Dawson

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Parkinson's Disease

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

SMAC KO Lines for Drug Discovery

C04651: SMAC KO Lines for Drug Discovery Technical Details: Second mitochondrial-derived activator of caspase (SMAC; also known as Diablo) gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Kohli et al., 2004 Looking for Partners: The cell lines described in this invention can be used in...

Published: 6/27/2024 | Inventor(s): Manu Kohli, Lin Zhang, Kenneth Kinzler, Christoph Lengauer, Jian Yu, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

A Cell Line with Targeted Deletions of both Bax and p21

C04312: A Cell Line with Targeted Deletions of both Bax and p21 Technical Details: A Bax and p21 knock out cell line in human colorectal cancer cells. Details are described in the papers by Zhang et al. (2000) and Yu et al. (2003). Looking for Partners: Cells that lack both a functional BAX and p21 gene are relatively resistant to apoptosis....

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Lin Zhang, Jian Yu, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

A p105-based NF-(kappa) B Super repressor

C04290: A p105-based NF-(kappa) B Super repressor Technical Details: Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological...

Published: 6/27/2024 | Inventor(s): Li Lin

Keywords(s): Biologics, Cancers, Chemotherapy, Disease Indication, Nucleic Acid, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Isogenic Cell Lines with or without Intact BAX Genes

C04218: Isogenic Cell Lines with or without Intact BAX Genes Technical Details: To assess the role of BAX in drug-induced apoptosis in human colorectal cancer cells, we generated cells that lack functional BAX genes. Such cells were partially resistant to the apoptotic effects of the chemotherapeutic agent 5-fluorouracil, but apoptosis was not abolished....

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Lin Zhang, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

PUMA Mediates the Apoptotic Response to p53

C04140: PUMA Mediates the Apoptotic Response to p53 Technical Details: The p53 pathway is inactivated in the great majority of human cancers. Of the many physiologic effects of p53 that have been described, current evidence suggests that apoptosis is critical for its tumor suppressor activities. Although several genes that might mediate p53-induced...

Published: 6/27/2024 | Inventor(s): Lin Zhang, Kenneth Kinzler, Bert Vogelstein, Jian Yu

Keywords(s): Biologics, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Gene Therapy, In Vitro Research Tool, Nucleic Acid, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Cell Lines