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TITLEIdentification of a novel AIF3 isoformCASE NUMBERC13339 ABSTRACTApoptosis-inducing factor (AIF) is a bifunctional flavoprotein with a vital function in bioenergetics within mitochondria and a lethal function in cell death when it moves to the nucleus. We identified a novel AIF isoform AIF3 in mouse brain by 5’ RACE. AIF3 lacks exons 2 and 3, which...

Published: 3/13/2025 | Inventor(s): Ted Dawson, Valina Dawson, Masayuki Sasaki, Yingfei Wang

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Growth Factors, Neurodegeneration, Neurodegenerative Diseases, Recombinant Proteins, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Generation of Leucine Rich Repeat Kinase-2 (LRRK2) Knockout Mice

C10385: Generation of Leucine Rich Repeat Kinase-2 (LRRK2) Knockout Mice Value Proposition: In order to understand the normal function of LRRK2, JHU faculty have generated a targeted mutation in the murine homolog of LRRK2. LRRK2 mice are viable, fertile and show no gross pathologic abnormalities.There are no significant difference in body weight,...

Published: 3/13/2025 | Inventor(s): Li Zhang, Valina Dawson, Masayuki Sasaki, Ted Dawson

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Parkinson's Disease

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools