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TITLEIdentification of a novel AIF3 isoformCASE NUMBERC13339 ABSTRACTApoptosis-inducing factor (AIF) is a bifunctional flavoprotein with a vital function in bioenergetics within mitochondria and a lethal function in cell death when it moves to the nucleus. We identified a novel AIF isoform AIF3 in mouse brain by 5’ RACE. AIF3 lacks exons 2 and 3, which...

Published: 3/13/2025 | Inventor(s): Ted Dawson, Valina Dawson, Masayuki Sasaki, Yingfei Wang

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Growth Factors, Neurodegeneration, Neurodegenerative Diseases, Recombinant Proteins, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Chemical Control of Trk Signaling in Mice

C04844: Chemical Control of Trk Signaling in Mice Technical Details: Neurotrophins are a family of molecules that encourage survival of nervous tissue by secreting factors in a neuron's target field, and act by prohibiting the neuron from apoptosis. The neurotrophin family include nerve growth factors nerve growth factor (NGF), Brain-derived...

Published: 3/13/2025 | Inventor(s): David Ginty, Xi Chen

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Growth Factors, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools