Search Results - david+ginty

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TH-2A-CreER Mice

Value Proposition· Enhanced labeling efficiency: The TH-2A-CreER mouse line achieves higher labeling efficiency compared to existing mouse lines through the 2A peptide system that ensures elevated CreER expression levels· Multi-population targeting: Enables labeling and functional manipulation of TH-expressing neuronal populations including...

Published: 10/23/2025 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

023046 B6.129S6(Cg)-Ntrk2tm2.1Ddg; 025417 STOCK Megf8tm1.2Ddg; 025418 C3;B6-Megf8m687Ddg; 025615 STOCK Islr2tm2.1Ddg; 027214 B6.129S6(Cg)-Ntrk2tm3.1(cre/ERT2)Ddg

Value Proposition· Comprehensive toolkit for mechanoreceptor research: Five complementary mouse strains that enable precise visualization, manipulation, and functional analysis of different mechanoreceptor populations and neural development pathways· Genetic precision: Each strain targets specific cell populations (Aδ-LTMRs, trigeminal neurons,...

Published: 10/23/2025 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Chemically-induced Mutations of Sema3a, Sec24b, and Megf8 in Mouse

Value Proposition· Novel loss-of-function mutations: Three distinct ENU-induced point mutations (Sema3A^K108N, Sec24b^Y613X, and Megf8^L1775P) that create specific loss-of-function phenotypes while maintaining protein expression and secretion· Validated genetic models: Each strain has been thoroughly characterized and phenotypically validated...

Published: 10/23/2025 | Inventor(s): Janna Merte, David Ginty

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Targeted Gfp Knock-in to the Islr2 (aka Linx) Locus

Value Proposition· Genetically modified mouse model with targeted GFP knock-in to the Islr2/Linx locus, enabling real-time visualization of specific neuronal populations during critical developmental windows· Dual functionality - the null mutation eliminates Linx protein to reveal functional defects (shorter, thinner nerves and stalled branching),...

Published: 10/23/2025 | Inventor(s): Kenji Mandai, David Ginty

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Model, Neurons, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

Chemically-induced Mutations of B3gnt1 and Ispd in Mouse

Value Proposition· Human disease relevance: Recapitulate key dystroglycanopathy features including cobblestone lissencephaly, neuronal migration defects, and muscular dystrophy· Complementary severity spectrum: B3gnt1 mutants survive to adulthood with mild symptoms; Crppa mutants show severe early phenotypes· Drug discovery ready: Enable...

Published: 10/23/2025 | Inventor(s): Kevin Wright, David Ginty

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Congenic, targeted mutant mouse line B6.129S6(Cg)-Ntrk1 ::superscript-tm2Ddg::/J (aka B6.Cg-Ntrk1::superscript-tm2DdG::/J)

Value Proposition· Visualization tool: FLAG-tagged TrkA knock-in mouse that allows direct tracking of endogenous TrkA receptor trafficking and signaling in living neurons· Physiologically relevant: Unlike overexpression systems, this model maintains normal TrkA expression levels and regulation from the endogenous locus· Versatile research...

Published: 10/30/2025 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Chemically-induced mutant mouse line C3.B6-Erbb3::superscript-m3329Ddg::/J (aka C3.B6-Erbb3::superscript-I449S::/DdgJ )

Value Proposition· Novel genetic model for studying peripheral nervous system development - The Erbb3^I449S mutation provides a unique loss-of-function model that specifically affects nerve fasciculation and branching· Precise developmental timing - Embryonic lethality at day 14.5 allows for detailed study of early peripheral nerve development...

Published: 10/30/2025 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology

TrkB(f/f) Mouse

Value Proposition· Conditional TrkB knockout capability: Floxed TrkB alleles enable precise spatial and temporal control over TrkB deletion when combined with Cre recombinase systems· Tissue-specific targeting: Allows researchers to delete TrkB in specific cell types or brain regions while preserving function elsewhere· Developmental...

Published: 10/30/2025 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

TrkB-F616A

Value Proposition· Drug-sensitive TrkB receptors: F616A mutation creates unique binding pocket allowing selective inhibition by specific small molecules· BDNF pathway research tool: Enables targeted study of the most clinically relevant neurotrophin signaling pathway in neuropsychiatric disorders· Selective inhibition capability: Mutant...

Published: 10/30/2025 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Polyclonal Antisera Specific for Neuropilin-1 and Polyclonal Antisera Specific for Neuropilin-2

C10703: Polyclonal Antibodies for Neuropilin-1 (Npn-1) and Polyclonal Antibodies for Neuropilin-2 (Npn-2)Value Proposition: These are rabbit polyclonal antibodies directed against the rodent proteins neuropilin-1 and neuropilin-2. The neuropilins are semaphorin receptors.Technical Details: The semaphorin family contains a large number of phylogenetically...

Published: 10/30/2025 | Inventor(s): David Ginty, Alex Kolodkin

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Polyclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools

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