Search Results - harith+rajagopalan

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C04654: RAF KO Lines for Drug Discovery Technical Details: BRAF kinase gene knockouts of human cancer cell lines.Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target the RAF pathway in human cancer cells or to confirm the specificity of drugs discovered through other approaches. Such...

Published: 6/27/2024 | Inventor(s): Harith Rajagopalan, Christoph Lengauer, Victor Velculescu, Jihye Yun, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Human Cancer Cell Lines Deficient in the CDC4 Gene

C04300: Human Cancer Cell Lines Deficient in the CDC4 Gene Technical Details: To assess the role of CDC4 in genetic instability, we generated cells that lack functional CDC4 genes. An abnormal chromosome number (aneuploidy) is a hallmark of human cancer, recognized for nearly a century. However, the mechanism(s) responsible for aneuploidy has remained...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Harith Rajagopalan, Christoph Lengauer, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker