Search Results - yardena+samuels

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ApoC1 KO Cells

C10769: ApoC1 KO Cells Technical Details: ApoC1 knockout inhuman colorectal cancer cell line HCT116.Looking for Partners: The cell lines described can be used in screens for novel molecules that target the ApoC1 pathway in human cancer cells to confirm the specificity of drugs discovered through other approaches. Such drugs can potentially be used...

Published: 6/27/2024 | Inventor(s): Victor Velculescu, Kenneth Kinzler, Yardena Samuels, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Epithelial Cells, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Human Cell Lines

Mutational Analysis of the Serine-threonine Kinome in Colorectal Cancers

C04724: Mutational Analysis of the Serine-threonine Kinome in Colorectal Cancers Technical Details: The invention describes novel mutations in serine-threonine kinase genes within the Phosphatidylinositol-3-OH Kinase (PI(3)K) pathway in patients with colorectal cancer. Details are described in the paper by Parsons et al., 2005 (see below). Looking...

Published: 6/27/2024 | Inventor(s): Alberto Bardelli, Christoph Lengauer, Yardena Samuels, Donald Parsons, Tian-Li Wang, Kenneth Kinzler, Victor Velculescu, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

PIK3CA KO Lines for Drug Discovery

C04652: PIK3CA KO Lines for Drug Discovery Technical Details: PIK3CA knockouts in human colorectal cancer cell lines HCT116 and DLD1. Details are described in the paper by Samuels et al., 2005 Looking for Partners: JHU scientists have recently discovered that mutations in PIK3CA occur in a significant fraction of cancers. Knockout lines indicated...

Published: 6/27/2024 | Inventor(s): Victor Velculescu, Yardena Samuels, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools