Search Results - epithelial+cells

12 Results

Sort By:

K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells

C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...

Published: 3/13/2025 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Exon 20 Wildtype Control Knock in MCF-10A Cells

TITLE Exon 20 Wildtype Control Knock in MCF-10A Cells DESCRIPTION A human breast epithelial cell line (MCF-10A) with gene targeting resulting in no change in the PIK3CA gene after homologous recombination, (wildtype control). TANGIBLE MATERIAL: Human PIK3CA (H1047R/+) MCF10A Cell Line ASSOCIATED INSTITUTION Oncology, School of Medicine PI:...

Published: 3/13/2025 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

CF8Flp: A Cystic Fibrosis Bronchial Epithelial Cell Line with a Single Integration Site for the Stable Expression of any Gene of Interest

A Cystic Fibrosis Bronchial Epithelial Cell Line (CF8Flp)JHU REF: C12966Invention Novelty: The invention is in the form of a Cystic Fibrosis Bronchial Epithelial Cell Line with an integration site that allows for stable expression of the target protein.Value Proposition:Bronchial epithelial cells have been particularly instrumental in providing a means...

Published: 3/13/2025 | Inventor(s): Garry Cutting

Keywords(s): Basic Research Biomarker, Cell Model, Cloning Reagents, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis

Deletion of Kelch-like ECH-associated Protein 1 (Keap1) in Kidney Epithelial Cells Causes Hydronephrosis in Mice

Invention novelty: This invention reveals an unexpected, novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development.Value Proposition:The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and...

Published: 3/13/2025 | Inventor(s): Samatha Bandapalle, Sanjeev Noel, Hamid Rabb

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, Disease Indication, Epithelial Cells, In Vitro Research Tool, Kidney Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

ApoC1 KO Cells

C10769: ApoC1 KO Cells Technical Details: ApoC1 knockout inhuman colorectal cancer cell line HCT116.Looking for Partners: The cell lines described can be used in screens for novel molecules that target the ApoC1 pathway in human cancer cells to confirm the specificity of drugs discovered through other approaches. Such drugs can potentially be used...

Published: 3/13/2025 | Inventor(s): Victor Velculescu, Kenneth Kinzler, Yardena Samuels, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Epithelial Cells, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Human Cell Lines

AKT1 Knock in Cells

C10605: AKT1 Knock in Cells Value Proposition: JHU scientists have generated a cell line incorporating a single base pair mutation “knocked in” within the AKT1 oncogene, single allele, into the MCF-10A human breast epithelial cell line resulting in a heterozygous E17K amino acid change. Additionally, a control “knock in” wild type cell line was...

Published: 3/13/2025 | Inventor(s): Josh Lauring, Ben Ho Park

Keywords(s): Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Estrogen Receptor in Knock out (ERIK) Cells

C10036: Estrogen Receptor in Knock out (ERIK) Cells Technical Details: Receptor positive non-tumorigenic human breast epithelial cell line derived from the commercially available MCF-10A human breast epithelial cell line with the p21 gene somatically deleted. Looking for Partners: The cell lines described in this invention can be used in screens...

Published: 3/13/2025 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

PIK3CA Exon 9 and Exon 20 Knock in Cells

C10035: PIK3CA Exon 9 and Exon 20 Knock in Cells Technical Details: PIK3CA exon 9 and exon 20 knock in cells within the MCF-10A human breast epithelial cell line. Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target the PIK3CA pathway in human cancer cells or to confirm the specificity...

Published: 3/13/2025 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

C04772: S9, A Cystic Fibrosis bronchial epithelial cell line Technical Details: Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?508 /W1282X. IB3-1 Cells were immortalized with adeno12SV0 and later infected with a viral vector AAV carrying CFTR full length.Looking for Partners: This cell line may be useful in...

Published: 3/13/2025 | Inventor(s): William Guggino, Terence Flotte, Pamela Zeitlin

Keywords(s): Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

C38

C04744: C38 Technical Details: JHU scientists have created a Cystic Fibrosis bronchial epithelial cell line that was isolated from a patient with genotype ?508/W1282X. Cells were immortalized with adeno12SV0 and later transfected with a cDNA from AAV carrying CFTR truncated for the first 119 amino acids.Looking for Partners: This cell line may be...

Published: 3/13/2025 | Inventor(s): Pamela Zeitlin, William Guggino, Terence Flotte

Keywords(s): Adeno-Associated Virus, Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Research Reagent, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

1 2