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Deletion of Kelch-like ECH-associated Protein 1 (Keap1) in Kidney Epithelial Cells Causes Hydronephrosis in Mice

Invention novelty: This invention reveals an unexpected, novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development.Value Proposition:The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and...

Published: 3/13/2025 | Inventor(s): Samatha Bandapalle, Sanjeev Noel, Hamid Rabb

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, Disease Indication, Epithelial Cells, In Vitro Research Tool, Kidney Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools