Search Results - josh+lauring

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GATA3 wild type MCF-7 breast cancer cells GATA3 D336fs*17 mutant CAMA1 breast cancer cells

Unmet NeedMutations in the transcription factor-encoding gene GATA3 are highly prevalent in breast cancer but the functional role of mutant GATA3 in malignancy remains unclear due in part to the absence of appropriate research tools. Human breast cancer cell lines with mutant and wild-type GATA3, including MCF-7 and CAMA1, respectively, are commercially...

Published: 3/13/2025 | Inventor(s): Josh Lauring, John Gustin

Keywords(s): Basic Research Biomarker, Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Research Tools > Cell Lines

PIK3CA wild type and AKT1 E17K and PIK3CA H1047R knock-in MCF-7 cells

C12186: PIK3CA Wild Type and AKT1 E17K and PIK3CA H1047R Knock-in MCF-7 CellsNovelty: MCF-7 derivatives with different mutations in the phosphatidylinositol-3-kinase (PI3-kinase) pathway gene PIK3CA and AKT1.Value Proposition: MCF-7 is the most widely used human breast cancer cell line, and it serves as a valuable model for preclinical investigations...

Published: 3/13/2025 | Inventor(s): Ben Ho Park, Josh Lauring

Keywords(s): Breast Cancer, Cancer Cells, Cancers, Cell Lines, Cell Model, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

AKT1 Knock in Cells

C10605: AKT1 Knock in Cells Value Proposition: JHU scientists have generated a cell line incorporating a single base pair mutation “knocked in” within the AKT1 oncogene, single allele, into the MCF-10A human breast epithelial cell line resulting in a heterozygous E17K amino acid change. Additionally, a control “knock in” wild type cell line was...

Published: 3/13/2025 | Inventor(s): Josh Lauring, Ben Ho Park

Keywords(s): Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

MMSET Knock Out and Knock Down Multiple Myeloma Cells

C10575: MMSET Knock Out and Knock Down Multiple Myeloma Cells Value Proposition: • Effective knockout/knockdown Multiple Myeloma cells line for the study of t(4;14)(p16;q32), worst prognostic subgroup in Multiple Myeloma Patients. Technical Details: Multiple myeloma (MM) is an incurable hematologic malignancy characterized by recurrent chromosomal...

Published: 3/13/2025 | Inventor(s): Josh Lauring, Ben Ho Park

Keywords(s): Basic Research Biomarker, Blood Cancer, Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, Hematologic Malignancies, In Vitro Research Tool, Multiple Myeloma

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Oncology > Multiple Myeloma, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines