Search Results - william+guggino

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Modulation of ABCG2-mediated Urate Transport to Treat Hyperuricemia and Gout

C10666: Treatment of Hyperuricemia and Gout Technical Details: About 3 million people in U.S. are suffering from insufficiently treated gout. Incidence has more than tripled in the past 20 years, as the disease is correlated with being overweight, drinking too much alcohol, or having diets too high in meat or fish. It is well established that gout...

Published: 9/26/2024 | Inventor(s): Owen Woodward, William Guggino, Josef Coresh, Anna Kottgen, Michael Kottgen

Keywords(s): Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Gout, Inflammatory Disorders, Mechanism-of-action Biomarker, Molecular Switches/Receptors, Research Reagent, Therapeutic Matter, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation > Gout, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Inflammation, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Targets

C04772: S9, A Cystic Fibrosis bronchial epithelial cell line Technical Details: Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?508 /W1282X. IB3-1 Cells were immortalized with adeno12SV0 and later infected with a viral vector AAV carrying CFTR full length.Looking for Partners: This cell line may be useful in...

Published: 9/26/2024 | Inventor(s): William Guggino, Terence Flotte, Pamela Zeitlin

Keywords(s): Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

C38

C04744: C38 Technical Details: JHU scientists have created a Cystic Fibrosis bronchial epithelial cell line that was isolated from a patient with genotype ?508/W1282X. Cells were immortalized with adeno12SV0 and later transfected with a cDNA from AAV carrying CFTR truncated for the first 119 amino acids.Looking for Partners: This cell line may be...

Published: 9/26/2024 | Inventor(s): Pamela Zeitlin, William Guggino, Terence Flotte

Keywords(s): Adeno-Associated Virus, Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Research Reagent, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

IB3-1

C04681: IB3-1 Technical Details: Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?F508 /W1282X. Cells were immortalized with adeno12SV0.Looking for Partners: This cell line will be useful for the identification of drugs that treat cystic fibrosis.Publications Am J Physiol Cell Physiol. 2000 Feb;278(2):C259-67Sin...

Published: 9/26/2024 | Inventor(s): William Guggino, Pamela Zeitlin

Keywords(s): Adeno Virus, Basic Research Biomarker, Cell Model, Cystic Fibrosis, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Research Reagent, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools