Search Results - jordan+cummins

4 Results

Sort By:

Discovery of human miRNAs and their evaluation with a Dicer KO line

Unmet NeedMicroRNAs (miRNAs) are a class of small noncoding RNAs that have important developmental and regulatory roles in multicellular organisms. There is considerable evidence to indicate that miRNAs and their biogenesis protein machinery (e.g., Dicer) are involved in the development of cancer.To identify novel miRNAs several approaches have been...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Victor Velculescu, Jordan Cummins, Bert Vogelstein

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, In Vitro Diagnostics

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

HAUSP KO Lines for Drug Discovery

C04658: HAUSP KO Lines for Drug Discovery Technical Details: HAUSP (also known as USP7) deubiquitinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Cummins et al., 2004a (see below) Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules...

Published: 6/27/2024 | Inventor(s): Jordan Cummins, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Assay, Cancers, Cell Lines, Clinical Diagnostics, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Human Cell Lines, In Vitro Diagnostics, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

XIAP KO Lines for Drug Discovery

C04657: XIAP KO Lines for Drug Discovery Technical Details: X-linked inhibitor of apoptosis protein (XIAP) gene knockouts of human colon cancer cell lines. Details are described in the paper by Cummins et al., 2004 (see below). Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Jordan Cummins, Fred Bunz, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Dicer KO Lines for Drug Discovery

C04653: Dicer KO Lines for Drug Discovery Technical Details: Dicer RNase gene knockouts in human cell lines.Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target the miRNA pathway in human cancer cells or to confirm the specificity of siRNA-based drugs discovered through other appr...

Published: 6/27/2024 | Inventor(s): Jordan Cummins, Victor Velculescu, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools