Search Results - fred+bunz

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USP9X-deficient cancer cell linesJHU REF: [C11655]Invention novelty: The technology consists of colorectal cancer cell lines possessing a knockout mutation in the USP9X gene with/without an additional deletion of p53.Value PropositionThe cell lines present an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study...

Published: 6/27/2024 | Inventor(s): Dennis Harris, Fred Bunz

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Colorectal Cancer, Discovery/Research Tools, Disease Indication, In Vitro Research Tool

pSEPT Plasmid

C11082: High Efficiency Human Gene Targeting with Recombinant AAV and a Synthetic Exon Promoter Trap (SEPT) - pSept PlasmidValue Proposition: • SEPT targeting approach is generally useful in a variety of human cell lines • Simple method, eliminating need for customizing selectable marker for each gene targeted • The combined use...

Published: 6/27/2024 | Inventor(s): Fred Bunz

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

HCT116 CDK2-/-, HCT116 CDK2-/- p53-/- cells

C10680: HCT116 CDK2-/-, HCT116 CDK2-/- p53-/- cellsValue Proposition: ADVANTAGES • Somatic cell knockout • Cell line for validation of CDK2 inhibitors • Cell line for discovery of new anticancer therapeuticsTechnical Details: Cyclin Dependant Kinase 2 (CDK2) is a member of a large family of protein kinases that initiates...

Published: 6/27/2024 | Inventor(s): Jon Chung, Fred Bunz

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology

DLD-Chk1 S317A Cells

C10496: DLD-Chk1 S317A Cells Technical Details: Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development and tumor suppression. JHU scientists have engineered a somatic cell knock in that is deficient for the DNA damage induced activation of the Chk1 kinase. This cell line...

Published: 6/27/2024 | Inventor(s): Deborah Wilsker, Fred Bunz

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Cell Lines with Targeted Deletions of p53

C10083: Cell Lines with Targeted Deletions of p53 Technical Details: Cell lines with deletions of p53 can be used for testing the specificity of drugs that target the p53 pathway. This pathway is inactivated in multiple forms of tumors. The cells lines include the following: • HCT116 R248W/- • DLD1 R248W • DLD1 -/- • RKO -/- • SW48 -/-

Published: 6/27/2024 | Inventor(s): Ray Pagliarini, Nickolas Papadopoulos, Fred Bunz, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool

ATR-Seckel Cancer Cells for Drug Discovery

C04993: ATR-Seckel Cancer Cells for Drug Discovery Technical Details: Advanced gene targeting methods were used to generate biallelic knock-in point mutations in human colorectal cancer cells that cause a loss of ATR function, but retain enough activity to permit viability. JHU researchers determined that progression of the cancer cell cycle after...

Published: 6/27/2024 | Inventor(s): Fred Bunz

Keywords(s): Biomarker, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Colorectal Cancer, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Mechanism-of-action Biomarker, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

XIAP KO Lines for Drug Discovery

C04657: XIAP KO Lines for Drug Discovery Technical Details: X-linked inhibitor of apoptosis protein (XIAP) gene knockouts of human colon cancer cell lines. Details are described in the paper by Cummins et al., 2004 (see below). Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Jordan Cummins, Fred Bunz, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

CHK2 KO Lines for Drug Discovery

C04655: CHK2 KO Lines for Drug Discovery Technical Details: Chk2 protein kinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Jallepalli et al., 2003 (see below). Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target...

Published: 6/27/2024 | Inventor(s): Fred Bunz, Prasad Jallepalli, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Disruption of p53 in Human Cancer Cells Alters the Responses to Therapeutic Agents

C03920: Disruption of p53 in Human Cancer Cells Alters the Responses to Therapeutic Agents Technical Details: p53 knockout in human colorectal cancer cell line HCT116. Details are described in the paper by Bunz et al., 1999 Looking for Partners: The p53 gene is inactivated in the majority of human cancers. JHU scientists determined that p53...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Fred Bunz, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Lines, Cell Model, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool