Search Results - prasad+jallepalli

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C04655: CHK2 KO Lines for Drug Discovery Technical Details: Chk2 protein kinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Jallepalli et al., 2003 (see below). Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target...

Published: 3/13/2025 | Inventor(s): Fred Bunz, Prasad Jallepalli, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Securin is Required for Chromosomal Stability in Human Cells

C03816: Securin is Required for Chromosomal Stability in Human CellsValue Proposition: ADVANTAGES • hSecurin-/- cells exhibit chromosomal instability • hSecurin-/- cells are defective in their ability to execute anaphase • hSecurin-/- cells have gross aneuploidy • Method to screen for agents that inhibit aneuploidyTechnical...

Published: 3/13/2025 | Inventor(s): Prasad Jallepalli, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Assay, Biomarker, Cancers, Cell Signaling, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Inhibitors, Pharmakodynamic Biomarker, Research Reagent, Therapeutic Matter, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities