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Cell Lines with Targeted Deletions of p53

C10083: Cell Lines with Targeted Deletions of p53 Technical Details: Cell lines with deletions of p53 can be used for testing the specificity of drugs that target the p53 pathway. This pathway is inactivated in multiple forms of tumors. The cells lines include the following: • HCT116 R248W/- • DLD1 R248W • DLD1 -/- • RKO -/- • SW48 -/-

Published: 6/27/2024 | Inventor(s): Ray Pagliarini, Nickolas Papadopoulos, Fred Bunz, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

RAS KO Lines for Drug Discovery

C04733: RAS KO Lines for Drug Discovery Technical Details: RAS gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Parsons et al., 2005 Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target the RAS pathway in human cancer cells...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Victor Velculescu, Christoph Lengauer, Jihye Yun, Ray Pagliarini, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools