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Human Cancer Cell Line Deficient in the BLM Gene

C04297: Human Cancer Cell Line Deficient in the BLM Gene Technical Details: To assess the role of BLM in genetic instability, we generated cells that lack functional BLM genes. Genetic instability appears to be required for a normal colorectal epithelial cell to evolve into a cancerous one. Bloom syndrome patients have a strong predisposition to cancer...

Published: 6/27/2024 | Inventor(s): Carlo Traverso, Christoph Lengauer, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Colorectal Cancer, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools