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Search Results - meng+li
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Genetic Alterations in Medulloblastomas - MLL Genes as Targets for Diagnosis and Therapeutics
Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations,...
Published: 3/13/2025
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Inventor(s):
Xiaosong Zhang
,
Hai Yan
,
Gregory Riggins
,
Victor Velculescu
,
Kenneth Kinzler
,
Darell Bigner
,
Nickolas Papadopoulos
,
Donald Parsons
,
Sian Jones
,
Rebecca Leary
,
Meng Li
,
Bert Vogelstein
Keywords(s):
Biomarker
,
Brain Cancer
,
Cancers
,
Clinical Diagnostics
,
Diagnostic Biomarker
,
Disease Indication
,
In Vitro Diagnostics
,
Medulloblastoma
,
Therapeutic Matter
,
Therapeutics
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Neurology
,
Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > In Vitro Diagnostics
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
,
Technology Classifications > Therapeutic Modalities > Targets
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Technology Classifications > Diagnostics
,
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Therapeutic Modalities
,
Clinical and Disease Specializations > Oncology > Brain Cancer
,
Clinical and Disease Specializations > Oncology > Medulloblastoma
Methyl-BEAMing: Digital Quantification of DNA Methylation
C10690: Methyl-BEAMing: Digital Quantification of DNA MethylationValue Proposition: • Absolute quantification of the number of methylated molecule in a clinical sample • Sensitivity able to detect one methylated molecule in ~5,000 unmethylated molecules • BEAMing can assess millions of molecules simultaneously for the study of human...
Published: 3/13/2025
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Inventor(s):
Meng Li
,
Kenneth Kinzler
,
Nickolas Papadopoulos
,
Luis Diaz
,
Sanford Markowitz
,
Bert Vogelstein
Keywords(s):
Discovery/Research Tools
,
In Vitro Research Tool
,
Research Instrument
Category(s):
Technology Classifications > Research Tools
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