Search Results - luis+diaz

4 Results

Sort By:

Microsatellite Instability as a Pharmacogenomic Marker of Therapeutic Response to Immune Checkpoint Inhibition

TITLEMicrosatellite Instability as a Pharmacogenomic Marker of Therapeutic Response to Immune Checkpoint Inhibition CASE NUMBER C13241UNMET NEEDThe programmed death 1 (PD-1) pathway is a negative feedback system that represses Th1 cytotoxic immune responses and that, if unregulated, can damage the host. It is up-regulated in many tumors...

Published: 3/13/2025 | Inventor(s): Luis Diaz, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Dung Le, Drew Pardoll, Suzanne Topalian

Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics, Pharmakodynamic Biomarker

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

Mutations of ATRX in Brain Tumors

C11618: Novel Molecular Diagnostic for Aggressive Brain TumorsNovelty: A genetic mutation in the ATRX or DAXX genes previously unknown for its presence in various aggressive brain tumors was discovered and thereby provides an attractive diagnostic opportunity.Value Proposition: Previously unreported changes in ATRX or DAXX gene’s amino acid sequence...

Published: 3/13/2025 | Inventor(s): Luis Diaz, Alan Meeker, Hai Yan, Nickolas Papadopoulos, Darell Bigner, Yuchen Jiao, Ralph Hruban, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Biomarker, Brain Cancer, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers

DAXX/A TRX genes provide prognostic information in cancers

C11331: Methods and Biomarkers for the detection of Pancreatic Neuroendrocrine TumorsValue Proposition: • Mutations useful to accurately diagnose a patient with pancreatic neuroendocrine tumor • Novel prognostic indicators that predict clinical outcome • Genetic mutations identified that are useful to select and implement an appropriate...

Published: 3/13/2025 | Inventor(s): Nickolas Papadopoulos, Victor Velculescu, Luis Diaz, Yuchen Jiao, Kenneth Kinzler, Ralph Hruban, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Pancreatic Cancer, Prognostic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Methyl-BEAMing: Digital Quantification of DNA Methylation

C10690: Methyl-BEAMing: Digital Quantification of DNA MethylationValue Proposition: • Absolute quantification of the number of methylated molecule in a clinical sample • Sensitivity able to detect one methylated molecule in ~5,000 unmethylated molecules • BEAMing can assess millions of molecules simultaneously for the study of human...

Published: 3/13/2025 | Inventor(s): Meng Li, Kenneth Kinzler, Nickolas Papadopoulos, Luis Diaz, Sanford Markowitz, Bert Vogelstein

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Research Tools