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Microsatellite Instability as a Pharmacogenomic Marker of Therapeutic Response to Immune Checkpoint Inhibition

TITLEMicrosatellite Instability as a Pharmacogenomic Marker of Therapeutic Response to Immune Checkpoint Inhibition CASE NUMBER C13241UNMET NEEDThe programmed death 1 (PD-1) pathway is a negative feedback system that represses Th1 cytotoxic immune responses and that, if unregulated, can damage the host. It is up-regulated in many tumors...

Published: 6/27/2024 | Inventor(s): Luis Diaz, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Dung Le, Drew Pardoll, Suzanne Topalian

Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics, Pharmakodynamic Biomarker

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

Cancer Therapy via a Combination of Epigenetic Modulation and Immune Modulation

In addition to the conventional forms of cancer therapy (chemotherapy, surgery, radiation), newer forms of therapy, including epigenetic modulation with DNA demethylating agents and HDAC inhibitors and therapies targeted at the immune system, are being investigated. We have discovered that epigenetic modulation alters tumor gene expression so as to...

Published: 6/27/2024 | Inventor(s): Suzanne Topalian, Stephen Baylin, Drew Pardoll

Keywords(s): Antagonists/Inhibitors, Antibodies, Biologics, Biomarker, Cancers, Clinical Diagnostics, Combination, Disease Indication, Epigenetic, In Vitro Diagnostics, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Targeted Therapy/Immunotherapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities

MART-1 Phosphopeptides Restricted by HLA-DR1 for use as Melanoma Vaccines

C10691: Novel Peptides as a Melanoma Vaccine Value Proposition: • Phosphopeptides for use as vaccines for therapy and prevention of melanoma • Phosphopeptides for robust, diverse, and long-lasting anti-tumor immunity • Specific activity against whole melanoma tumor cells in vitro • Stand alone therapy/Combination Therapy •...

Published: 6/27/2024 | Inventor(s): Donald Hunt, Florence Depontieu, Angela Zarling, Victor Engelhard, Jeffrey Shabanowitz, Jie Qian, Suzanne Topalian

Keywords(s): Biologics, Cancers, Disease Indication, Immunotherapy, Melanoma, Peptide, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Melanoma, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Vaccines, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Johns Hopkins University PROTEIN-DB2 Database System

C04853: Johns Hopkins University PROTEIN-DB2 Database SystemNovelty: The current invention is a relational database for proteomic experiments.Value Proposition: Proteomic data collection follows complex workflow, ranging from gel electrophoresis to mass spectrometry to liquid chromatography or a combination thereof. In addition, amplification of low-abundance...

Published: 6/27/2024 | Inventor(s): Raimond Winslow, Stephen Granite, Chunguang Yang, Ali Ali, Donita Robinson

Keywords(s): Computer and Network Systems, Computer Software, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Databases