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Heavy Metal Multilayers for Pure Electrical Switching of Perpendicularly Magnetized Magnetic Unit Via Electrical Current Without Additional Magnetic Field, Method and Applications

Value Proposition· Novel Structure: Utilizes multiple layers of heavy metals to eliminate the need for an external magnetic field, simplifying design and reducing complexity.· Faster Computing: Eliminates reliance on external magnetic pulses, enabling faster computing and improved operational efficiency.· Higher-Density Storage: Streamlined...

Published: 1/22/2026 | Inventor(s): Qinli Ma, Yufan Li, Chia-Ling Chien

Keywords(s): Electric Communication Technique, Electricity

Category(s): Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment, Technology Classifications > Computers, Electronics & Software

SCA12 Tools – SCA12 Fibroblasts, iPSCs and Polyclonal Antibodies to Investigate SCA12

Value PropositionFirst in class patient-derived biological tools for investigation of SCA12, a rare neurodegenerative disease with no known cure. Unmet NeedSpinocerebellar ataxia type 12 (SCA12) is a rare neurodegenerative disease that affects the cerebellum, commonly resulting in upper limb tremors and muscle spasms, with some patients reporting a...

Published: 1/22/2026 | Inventor(s): Russell Margolis, Pan Li, Christopher Ross

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Neurology > Neurodegeneration

Anti-Fungal Drug Analogs to Treat Cancer by Preventing Angiogenesis and Hedgehog Pathway Activity

Value Proposition· Itraconazole is in clinical trials for cancer treatment as it is known to have antiangiogenic activity and anti-Hedgehog pathway activity, but its use has been limited by its potent inhibition of the drug metabolizing enzyme CYP3A4· The designed analog for itraconazole has greater antiangiogenic potency without CYP3A4 inhibition...

Published: 1/22/2026 | Inventor(s): Jun Liu, Wei Shi, Kalyan Kumar Pasunooti, Wukun Liu, Ruojing Li, Sarah Head, Yingjun Li

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Eye Disorders, Macular Degeneration, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration

Anti-Fungal Drug Analogs to Treat Cancer by Preventing Angiogenesis and Hedgehog Pathway Activity

Published: 1/22/2026 | Inventor(s): Jun Liu, Wei Shi, Kalyan Kumar Pasunooti, Wukun Liu, Ruojing Li, Sarah Head, Yingjun Li

Novel monoclonal antibody inhibitors targeting potassium channel KCNK9

Unmet Need:KCNK9 is one of 15 mammalian subtypes in the highly conserved family of two-pore domain potassium channels (K2P). Under physiological conditions, KCNK9 is primarily expressed in the brain where it serves to maintain cellular membrane potentials. However, overexpression of KCNK9 has been detected in breast, lung, skin, and other cancers, and...

Published: 1/22/2026 | Inventor(s): John Laterra, Han Sun, Min Li, Amy Fulton

Keywords(s): Antibodies, Biologics, Breast Cancer, Cancers, Disease Indication, Lung Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer

Software Tools for Tomographic Reconstruction

Value Proposition· Superior Image Quality – the proposed nonlinear DPS method outperforms traditional reconstruction methods and linear DPS models, offering better high-quality images across different acquisition protocols compared to conditionally trained deep learning approaches· State-of-the-Art Reconstruction – cutting-edge implementations...

Published: 1/22/2026 | Inventor(s): Joseph Stayman, Xiao Jiang, Shudong Li, Altea Lorenzon, Peiqing Teng

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

Flux Qubit based on Spin-triplet Superconductors

Value Proposition· Improved consistency of magnetic field generation · Easier fabrication · Reduced energy costs· Enhanced computing capabilitiesUnmet Need· As the computational demands of society progress, so does the need for inventive approaches to increasing computing power. The foundation of quantum computing is the...

Published: 1/22/2026 | Inventor(s): Chia-Ling Chien, Xiaoying Xu, Yufan Li

Keywords(s):

Category(s): Technology Classifications > Engineering Tech > Electrical Engineering, Technology Classifications > Engineering Tech > Materials

Digital Twin Operating Rooms for Virtual Reality Applications

Value PropositionArtificial surgical training environments that are more reflective and realistic to surgical suites.More immersive surgical training using advanced virtual reality technology. Easy ability to create these environments for users since they can be constructed from casually acquired videos, such as from smartphones.Unmet NeedOne example...

Published: 1/22/2026 | Inventor(s): Mathias Unberath, Constantin Kleinbeck, Han Zhang, Benjamin Killeen, Zhaoshuo Li

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Education Tech

Extracellular Vesicle mediated nucleic acid treatment in vivo

Value Proposition· Effective: animal studies showed increased survival and decreased tumor burden in liver cancer model.· Fewer side effects: no immunological reactions or off-target effects· Multiple targets: targets the cancer-stroma interactionsUnmet Need· Many current and pipeline cancer therapeutics, including therapeutic...

Published: 1/22/2026 | Inventor(s): Ling Li, Stephen Gould, Florin Selaru

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Gut-specific serotonin transporter inhibitors for treatment of constipation

Value Proposition· Potent inhibition of serotonin transporter (SERT) in GI system· Luminally and or/peripherally-restricted SERT inhibitors· Result in enhanced action of serotonin in stimulation of GI motility· Spares the body of systemic and CNS effectsUnmet NeedConstipation-predominant IBS involves reduced gastrointestinal...

Published: 1/22/2026 | Inventor(s): Pankaj Pasricha, James Barrow, Qian Li, Pablo de Leon, Yifang Huang

Keywords(s): Antagonists/Inhibitors, Biomarker, Disease Indication, Gastrointestinal Disorders, Mechanism-of-action Biomarker, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Gastroenterology

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