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Software Tools for Tomographic Reconstruction
Value Proposition· Superior Image Quality – the proposed nonlinear DPS method outperforms traditional reconstruction methods and linear DPS models, offering better high-quality images across different acquisition protocols compared to conditionally trained deep learning approaches· State-of-the-Art Reconstruction – cutting-edge implementations...
Published: 3/14/2025
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Inventor(s):
Joseph Stayman
,
Xiao Jiang
,
Shudong Li
,
Altea Lorenzon
,
Peiqing Teng
Keywords(s):
Category(s):
Technology Classifications > Computers, Electronics & Software > Algorithms
,
Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis
Flux Qubit based on Spin-triplet Superconductors
Value Proposition· Improved consistency of magnetic field generation · Easier fabrication · Reduced energy costs· Enhanced computing capabilitiesUnmet Need· As the computational demands of society progress, so does the need for inventive approaches to increasing computing power. The foundation of quantum computing is the...
Published: 3/14/2025
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Inventor(s):
Chia-Ling Chien
,
Xiaoying Xu
,
Yufan Li
Keywords(s):
Category(s):
Digital Twin Operating Rooms for Virtual Reality Applications
Value PropositionArtificial surgical training environments that are more reflective and realistic to surgical suites.More immersive surgical training using advanced virtual reality technology. Easy ability to create these environments for users since they can be constructed from casually acquired videos, such as from smartphones.Unmet NeedOne example...
Published: 3/14/2025
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Inventor(s):
Mathias Unberath
,
Constantin Kleinbeck
,
Han Zhang
,
Benjamin Killeen
,
Zhaoshuo Li
Keywords(s):
Category(s):
Extracellular Vesicle mediated nucleic acid treatment in vivo
Value Proposition· Effective: animal studies showed increased survival and decreased tumor burden in liver cancer model.· Fewer side effects: no immunological reactions or off-target effects· Multiple targets: targets the cancer-stroma interactionsUnmet Need· Many current and pipeline cancer therapeutics, including therapeutic...
Published: 3/13/2025
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Inventor(s):
Ling Li
,
Stephen Gould
,
Florin Selaru
Keywords(s):
Drug Delivery Vehicle
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Therapeutic Matter
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Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
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Technology Classifications > Therapeutic Modalities
Gut-specific serotonin transporter inhibitors for treatment of constipation
Value Proposition· Potent inhibition of serotonin transporter (SERT) in GI system· Luminally and or/peripherally-restricted SERT inhibitors· Result in enhanced action of serotonin in stimulation of GI motility· Spares the body of systemic and CNS effectsUnmet NeedConstipation-predominant IBS involves reduced gastrointestinal...
Published: 3/13/2025
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Inventor(s):
Pankaj Pasricha
,
James Barrow
,
Qian Li
,
Pablo de Leon
,
Yifang Huang
Keywords(s):
Antagonists/Inhibitors
,
Biomarker
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Disease Indication
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Gastrointestinal Disorders
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Mechanism-of-action Biomarker
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Non-novel
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Predicted Novelty
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Repurposed
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Small Molecules
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Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Targets
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Clinical and Disease Specializations > Gastroenterology
Augmented or Virtual Reality Based Evaluation of Visual Field
Sensitive visual field assessment using augmented realityJHU Ref #: C17601Unmet NeedWhile visual field measurement is key in diagnosing and monitoring eye and systemic diseases in patients (American Academy of Ophthalmology, 2022), current practices are either quick but imprecise (confrontation visual field tests that rely on the doctor’s hand gestures...
Published: 3/14/2025
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Inventor(s):
Ali Saber Tehrani
,
Arash Saber Tehrani
Keywords(s):
Category(s):
Clinical and Disease Specializations > Ophthalmology
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Technology Classifications > Computers, Electronics & Software > Algorithms
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Technology Classifications > Computers, Electronics & Software > Machine Learning
Treatment of Irritable Bowel Syndrome with Molybdenum
Unmet NeedIrritable Bowel Syndrome is a chronic and incurable gastrointestinal disorder that affects 3-20% of Americans depending on certain sociocultural and comorbid factors. A poorly understood condition, current treatments consist of antispasmodics, antidiarrheals, and dietary restrictions. Unable to alleviate all its symptoms, researchers are in...
Published: 3/13/2025
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Inventor(s):
Pankaj Pasricha
,
Lian Sheng Liu
,
Qian Li
,
Alfred Spormann
Keywords(s):
Disease Indication
,
Gastrointestinal Disorders
,
Inflammatory Bowel Disease (IBD)
,
Small Molecules
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
Category(s):
Technology Classifications > Therapeutic Modalities > Small Molecules
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Clinical and Disease Specializations > Gastroenterology > Irritable Bowel Disease
Large-scale Epigenomic Reprogramming Links Anabolic Glucose Metabolism to Distant Metastasis during the Evolution of Pancreatic Cancer Progression
Unmet NeedPancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer death in the western world by 2020. Subclonal populations that emerge and drive metastatic progression of the disease are associated with high mortality rates among patients. Blocking the tumorigenic potential of metastatic sites is key to improving...
Published: 3/13/2025
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Inventor(s):
Andrew Feinberg
,
Xin Li
,
Christine Iacobuzio-Donahue
,
Oliver McDonald
Keywords(s):
Biomarker
,
Cancers
,
Clinical Diagnostics
,
Diagnostic Biomarker
,
Disease Indication
,
In Vitro Diagnostics
,
Mechanism-of-action Biomarker
,
Pancreatic Cancer
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Gastroenterology
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Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Diagnostics > Diagnostic Biomarkers
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Technology Classifications > Diagnostics > In Vitro Diagnostics
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Technology Classifications > Diagnostics
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Clinical and Disease Specializations > Oncology
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Clinical and Disease Specializations > Oncology > Pancreatic Cancer
Polymers for Binding-Triggered Antibody Precipitation and Purification
Value PropositionResults in >97% precipitation yield, >88% elution yield of mAbsSimplified molecular design compared to elastin-like polypeptide (ELP)-based materialsDoes not need additional salt to achieve mAb precipitation and recoveryTechnology DescriptionResearchers at Johns Hopkins have developed a peptide-based platform technology using...
Published: 3/14/2025
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Inventor(s):
Honggang Cui
,
Yi Li
,
David Stern
,
XuanKuo Xu
,
Lye Lin Lock
,
Jason Mills
,
Sanchayita Ghose
,
Zheng Jian Li
Keywords(s):
Category(s):
Clinical and Disease Specializations > Immunology
,
Clinical and Disease Specializations > Research Tools
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Technology Classifications > Research Tools > Antibodies
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Technology Classifications > Research Tools > Research Antibodies
,
Technology Classifications > Therapeutic Modalities > Antibodies
,
Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies
Polymers for Binding-Triggered Antibody Precipitation and Purification
Value PropositionResults in >97% precipitation yield, >88% elution yield of mAbsSimplified molecular design compared to elastin-like polypeptide (ELP)-based materialsDoes not need additional salt to achieve mAb precipitation and recoveryTechnology DescriptionResearchers at Johns Hopkins have developed a peptide-based platform technology using...
Published: 3/14/2025
|
Inventor(s):
Honggang Cui
,
Yi Li
,
David Stern
,
XuanKuo Xu
,
Lye Lin Lock
,
Jason Mills
,
Sanchayita Ghose
,
Zheng Jian Li
Keywords(s):
Category(s):
Clinical and Disease Specializations > Immunology
,
Clinical and Disease Specializations > Research Tools
,
Technology Classifications > Research Tools > Antibodies
,
Technology Classifications > Research Tools > Research Antibodies
,
Technology Classifications > Therapeutic Modalities > Antibodies
,
Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies
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