Search Results - stephen+gould

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Extracellular Vesicle mediated nucleic acid treatment in vivo

Value Proposition· Effective: animal studies showed increased survival and decreased tumor burden in liver cancer model.· Fewer side effects: no immunological reactions or off-target effects· Multiple targets: targets the cancer-stroma interactionsUnmet Need· Many current and pipeline cancer therapeutics, including therapeutic...

Published: 3/13/2025 | Inventor(s): Ling Li, Stephen Gould, Florin Selaru

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Method for Surface Expression of Membrane Proteins that have a Cytoplasmic C-terminal Tail

Enhanced Vaccine Development through Optimized Antigen DisplayJHU Ref #: C16777Value Proposition· Improved antigenicity due to increased cell surface expression of viral proteins · Boosts vaccine efficacy · Potential for integration into various vaccine platforms, including viral-mediated, mRNA-mediated, and DNA-mediated vaccines Unmet...

Published: 3/14/2025 | Inventor(s): Stephen Gould, Linda Marban, Chenxu Guo, Shang-Jui Tsai

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Genetic Enhancement of Exosome Production

This invention solves the problem of how to increase the yield of exosomes, as well as how to create genetically modified exosomes.Unmet NeedEach year in the US, ~1.7 million new patients are diagnosed with cancer and of those, 600,000 will die (see CDC 2022). The treatment of many cancers relies on the delivery of drugs (small molecules, peptides,...

Published: 3/14/2025 | Inventor(s): Stephen Gould, Shang-Jui Tsai, Yiwei Ai, Chenxu Guo

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

An Exosome Display Spike Vaccine

Unmet NeedNext-generation vaccines are needed to address the emergence of new pathogens, the limitations of current vaccine technologies, and the need for more effective and durable immunity against complex diseases like cancer, HIV, and emerging viruses. Traditional vaccines require long production timelines, often require cold storage, multiple doses,...

Published: 3/14/2025 | Inventor(s): Stephen Gould, Chenxu Guo, Shang-Jui Tsai

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Category(s): Technology Classifications > Therapeutic Modalities > Vaccines

Cell Lines Carrying Mutations in Genes of Interest

TITLE: Cell lines carrying mutations in genes of interestCASE NUMBER: C13619ABSTRACTThe invention is a series of cell lines. Each cell line carries mutations in a specific gene of interest. The mutant cell lines were generated by (a) transfecting a cell line with a proprietary gRNA/Cas9-3xNLS/FP/TK/puro expression plasmid designed to create double strand...

Published: 3/13/2025 | Inventor(s): Stephen Gould

Keywords(s): Cell Lines, Discovery/Research Tools, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Polycistronic Plasmids for Mutating Genes

TITLE: Polycistronic plasmids for mutating genesCASE NUMBER: C13607ABSTRACTThe invention is a series of plasmids. Each plasmid drives the expression of (a) two (2) PolIII transcripts encoding CRISPR-based guide RNAs (gRNAs) that target a specific gene and (b) one (1) PolI transcript that expresses a polycistronic ORF encoding (i) Sp Cas9 protein fused...

Published: 3/13/2025 | Inventor(s): Stephen Gould

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools