Search Results - shang-jui+tsai

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Method for Surface Expression of Membrane Proteins that have a Cytoplasmic C-terminal Tail

Enhanced Vaccine Development through Optimized Antigen DisplayJHU Ref #: C16777Value Proposition· Improved antigenicity due to increased cell surface expression of viral proteins · Boosts vaccine efficacy · Potential for integration into various vaccine platforms, including viral-mediated, mRNA-mediated, and DNA-mediated vaccines Unmet...

Published: 3/14/2025 | Inventor(s): Stephen Gould, Linda Marban, Chenxu Guo, Shang-Jui Tsai

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Genetic Enhancement of Exosome Production

This invention solves the problem of how to increase the yield of exosomes, as well as how to create genetically modified exosomes.Unmet NeedEach year in the US, ~1.7 million new patients are diagnosed with cancer and of those, 600,000 will die (see CDC 2022). The treatment of many cancers relies on the delivery of drugs (small molecules, peptides,...

Published: 3/14/2025 | Inventor(s): Stephen Gould, Shang-Jui Tsai, Yiwei Ai, Chenxu Guo

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

An Exosome Display Spike Vaccine

Unmet NeedNext-generation vaccines are needed to address the emergence of new pathogens, the limitations of current vaccine technologies, and the need for more effective and durable immunity against complex diseases like cancer, HIV, and emerging viruses. Traditional vaccines require long production timelines, often require cold storage, multiple doses,...

Published: 3/14/2025 | Inventor(s): Stephen Gould, Chenxu Guo, Shang-Jui Tsai

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Category(s): Technology Classifications > Therapeutic Modalities > Vaccines