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Flux Qubit based on Spin-triplet Superconductors

Value Proposition· Improved consistency of magnetic field generation · Easier fabrication · Reduced energy costs· Enhanced computing capabilitiesUnmet Need· As the computational demands of society progress, so does the need for inventive approaches to increasing computing power. The foundation of quantum computing is the...

Published: 3/14/2025 | Inventor(s): Chia-Ling Chien, Xiaoying Xu, Yufan Li

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Extracellular Vesicle mediated nucleic acid treatment in vivo

Value Proposition· Effective: animal studies showed increased survival and decreased tumor burden in liver cancer model.· Fewer side effects: no immunological reactions or off-target effects· Multiple targets: targets the cancer-stroma interactionsUnmet Need· Many current and pipeline cancer therapeutics, including therapeutic...

Published: 3/13/2025 | Inventor(s): Ling Li, Stephen Gould, Florin Selaru

Keywords(s): Drug Delivery Vehicle, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Local Sustained-release Nanocrystal Formulations to Treat and Prevent GI Fibrosis

Unmet Need: Gastrointestinal (GI) fibrosis, the accumulation of scar tissue in the intestinal wall as a complication in common GI autoimmune diseases such as ulcerative colitis (UC) and Crohn’s disease (CD), leads to intestinal strictures, abdominal pain, and reduced intestinal motility. Current pharmacological and surgical treatment methods have significant...

Published: 3/14/2025 | Inventor(s): Laura Ensign-Hodges, Florin Selaru, Min Kyung Joo, Rachel Shapiro, Ling Li

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Category(s): Clinical and Disease Specializations > Gastroenterology

New use of Sulconazole to Treat and Prevent GI Fibrosis

Published: 3/14/2025 | Inventor(s): Florin Selaru, Laura Ensign-Hodges, Ling Li, Min Kyung Joo

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Category(s): Clinical and Disease Specializations > Gastroenterology

Precision Transport, Positioning, and Assembling of Longitudinal Nano-entities

A vast variety of nano-materials made of metallic, semiconductive, magnetic, and polymers have been fabricated into 0D dots, rings, 1D wires/tubes, 2D films, and 3D architectures. Among them, 1D nanostructured wires/tubes have become the focus of recent research. Extensive work reveals that nanowires and nanotubes have unique electronic, optical, magnetic,...

Published: 3/13/2025 | Inventor(s): Donglei Fan, Robert Cammarata, Chia-Ling Chien

Keywords(s): Industrial Manufacturing, Manufactured Devices, Manufacturing Method, Microfabrication, Nanowires, Wires

Category(s): Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Industrial Manufacturing

Spontaneous Half-quantum Flux Qubit Constructed with Novel Superconducting Materials

Unmet NeedThere is a need for improved quantum computing technology outside the standard superconducting loops where are currently in the process of being developed by a number of major corporations and research institutions. Superconducting loops require extensive cryogenic isolation and have comparably low longevity and logic success rates. In comparison...

Published: 3/14/2025 | Inventor(s): Chia-Ling Chien, Yufan Li, Xiaoying Xu

Keywords(s): Computer and Network Systems, Computer Hardware, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Physics

Category(s): Technology Classifications > Computers, Electronics & Software

Locoregional Chemotherapy for Liver Cancers

Unmet NeedOver 800,000 people are diagnosed with liver cancer annually. As the leading cause of cancer death worldwide, liver cancer accounts for more than 700,000 deaths annually. Recently, Johns Hopkins researchers have developed new chemotherapeutic drugs to treat liver cancer that demonstrate higher efficacy than the current standard of care for...

Published: 3/14/2025 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Drug Delivery Mechanism, Liver Cancer, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Repurposed Drugs, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology > Liver Cancer

Liver-directed gene delivery via endoscopic retrograde cholangiopoancreatograpy (ERCP) directed hydrodynamic injection

Unmet NeedGene therapies are regarded as a potential revolution in the health sciences and pharmaceutical fields. The number of gene therapy trials has been steadily increasing in the United States, with around 170 trials taking place in 2015. All of these trials aim to treat the causes of different diseases instead of only relieving symptoms. Many...

Published: 3/14/2025 | Inventor(s): Florin Selaru, Vivek Kumbhari, Ling Li

Keywords(s): Drug Delivery Mechanism, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Mini-cancers Utilization as Decision Tools for Personalized Cancer Drug Regimens

The present invention includes methods for identifying chemotherapy treatments specifically suited for each cancer patient. The methods include obtaining a biopsy from the cancer patient; establishing a cancer culture from the biopsy; mixing the cancer culture with a matrix forming mini cancers. The mini cancers are then used to screen chemotherapy...

Published: 3/13/2025 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Topological Insulator-Based High Efficiency Switching of Magnetic Unit, Method and Application

Unmet Need: The invention meets the need for improved magnetic random access memory, racetrack memory, and spin logic devices. The present state of the art of electrical current by spin-orbital torque (SOT) consists of a single heavy metal layer (e.g., W or Ta) in contact with a ferromagnetic layer, which acquires perpendicular magnetic moment suitable...

Published: 3/13/2025 | Inventor(s): Yufan Li, Qinli Ma, Chia-Ling Chien

Keywords(s): Electric Communication Technique, Electricity, Industrial Manufacturing, Insulative Materials (Insulators), Novel Materials, Semiconductive Materials (Semiconductors), Topological Insulators

Category(s): Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Industrial Tech, Technology Classifications > Industrial Tech > Materials, Technology Classifications > Engineering Tech > Materials

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