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Detection of Low Abundant Molecules in Complex Mixture

Invention novelty: a method for quantitative, high-throughput analysis of glycans from tissue sections Value PropositionStudies on protein glycosylation have been complicated by the diverse structure of protein glycans and the lack of effective tools to identify the protein glycosylation site and glycan structure. Currently, mass spectrometry is the...

Published: 9/26/2024 | Inventor(s): Xingde Li, Shadi Eshghi, Hui Zhang

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Research Tools

Albumin-Flt3L Fusion Protein to Enhance Anti-Tumor Immunity and Antigen-specific T-cell Cytotoxicity

Unmet Need: Active immunotherapy, such as anti-PD-1/PD-L1 and anti-CTLA-4 checkpoint blockage, involves the administration of molecules to mobilize host immune cells to recognize and kill tumors. Proper presentation of tumor antigens through antigen presenting cells is a prerequisite to elicit a potent immune response. Current strategies enhance antigen...

Published: 9/26/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung, Brandon Lam

Keywords(s): Biologics, Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Research Instrument, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Immunology, Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets

Profiling of Interferon signaling to diagnose autoimmune disorders

Unmet Need / Invention Novelty: Diagnosing an autoimmune disease using standard laboratory tests is challenging and often requires secondary validation due to high rates of false positives and overlapping biological signatures with other diseases. There is a critical need for an improved method to detect autoimmune disease signatures in tissue collected...

Published: 9/26/2024 | Inventor(s): Livia Casciola-Rosen, Antony Rosen, John Hall

Keywords(s): Autoimmune Diseases, Basic Research Biomarker, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Inflammatory Disorders, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Biomarkers, Clinical and Disease Specializations > Autoimmunity

SpinΩ – A Multi-well Bioreactor for Culturing 3D Organoids

UNMET NEEDSpinning bioreactors have been used for three-dimensional (3D) cell culture and generation of organ-like tissues (organoids). However, current spinning bioreactors available on the market (e.g. the Corning® disposable spinner flasks) have several major challenges including requiring a large volume of medium and incubator space, large sample-to-sample...

Published: 9/26/2024 | Inventor(s): Hongjun Song, Guo-li Ming, Mingxi Song, Christopher Hadiono, William Jeang, Ha Nam Nguyen, Xuyu Qian

Keywords(s): Bioreactor-based Manufacturing, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Industrial Manufacturing, Research Instrument, Stem Cells

Category(s): Technology Classifications > Research Tools, Technology Classifications > Industrial Tech > Bioreactors, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Bioreactors, Technology Classifications > Engineering Tech > Industrial Manufacturing

Method for Genetic Analysis of Plant Materials in Remote Testing Sites

Unmet NeedThe study of plant genetics has immense economic impacts as many crops are genetically modified to increase yields or provide resistance to herbicides and diseases. Because of these changes, many genetically modified crops have been heralded as having great potential in developing countries. Even in the United States today, approximately 92%...

Published: 9/26/2024 | Inventor(s): Tza-Huei Wang, Dong Shin, Fan-En Chen, Yue Yun

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Instrument, Research Reagent

Category(s): Technology Classifications > Research Tools > Specimen Handling, Technology Classifications > Engineering Tech > Agriculture

Grid of Responses Indicating Drug Sensitivity

Unmet NeedDrug development is a long and costly process characterized by a high degree of attrition. Cardiotoxicity is the most common reason for withdrawing candidate drugs from the development pipeline, with 30% of drugs withdrawn during the clinical development phase. Improvements in methodologies for assessing drug cardiotoxicity during preclinical...

Published: 9/27/2024 | Inventor(s): Leslie Tung, Adriana Blazeski

Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics (Old), In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays

A Miniature Microscope for Multi-contrast Optical Imaging in Animals

Unmet NeedThe past two decades have witnessed a surge of new imaging contrast agents and mechanisms, as well as seen the introduction of novel imaging techniques. One such exciting development is ‘multicontrast imaging’, where several distinct imaging techniques are combined to simultaneously interrogate multiple physiological variables. This kind of...

Published: 9/26/2024 | Inventor(s): Arvind Pathak, Nitish Thakor, Janaka Senarathna, Hang Yu

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Research Tools

Detection and Elimination of Colonic Co-colonization with Enterotoxigenic Bacteroides Fragilis and pks+ Escherichia Coli in the Prevention of Colon Cancer

Unmet NeedFamilial adenomatous polyposis (FAP) is a hereditary condition caused by a mutation in the APC tumor suppressor gene, with a reported incidence of 1 in 7,000 to 1 in 22,000 individuals. Patients with FAP develop thousands of colorectal polyps that will eventually become malignant, resulting in colorectal cancer later in life. The onset and...

Published: 9/26/2024 | Inventor(s): Cynthia Sears, Christine Craig, Drew Pardoll

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastric Cancer, In Vitro Diagnostics (Old), In Vitro Research Tool, Research Instrument

Category(s): Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays

Comprehensive Phenotyping Reveals Robust Determination to Cellular Biological Age

Technology OverviewJHU researchers have developed a platform to determine the cellular biological age of individuals based on quantifiable functional outputs of their cells. Using a comprehensive approach, of high-throughput single cell technologies to measure biochemical and biophysical properties of cells, we have further developed a generalized linear...

Published: 9/26/2024 | Inventor(s): Jude Phillip, Denis Wirtz, Pei-Hsun Wu, Jeremy Walston

Keywords(s): Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, In Vitro Research Tool, Physics, Research Instrument

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools

Simulation and Database-guided Antimicrobial Peptide Evolution

Unmet Need Antimicrobial peptides (AMPs) are typically amphiphilic peptides that have selectively to target and kill bacteria at low micromolar concentrations, often without harming mammalian cells and are thus an excellent candidate for drug development.Technology OverviewThe new methodology combines molecular dynamic simulations and database-guided...

Published: 9/26/2024 | Inventor(s): Charles Chen, Martin Ulmschneider

Keywords(s): Computational Modeling Tool, Discovery/Research Tools, In Silico Research Tool, In Vitro Research Tool, Peptides, Recombinant Proteins, Research Instrument, Research Reagent

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Computers, Electronics & Software

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