Search Results - bioreactor-based+manufacturing

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SpinΩ – A Multi-well Bioreactor for Culturing 3D Organoids

UNMET NEEDSpinning bioreactors have been used for three-dimensional (3D) cell culture and generation of organ-like tissues (organoids). However, current spinning bioreactors available on the market (e.g. the Corning® disposable spinner flasks) have several major challenges including requiring a large volume of medium and incubator space, large sample-to-sample...

Published: 6/27/2024 | Inventor(s): Hongjun Song, Guo-li Ming, Mingxi Song, Christopher Hadiono, William Jeang, Ha Nam Nguyen, Xuyu Qian

Keywords(s): Bioreactor-based Manufacturing, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Industrial Manufacturing, Research Instrument, Stem Cells

Category(s): Technology Classifications > Research Tools, Technology Classifications > Industrial Tech > Bioreactors, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Bioreactors, Technology Classifications > Engineering Tech > Industrial Manufacturing

Hypoxia-inducible Hydrogels

Hypoxia, low oxygen tension, plays a pivotal role during development, regeneration, and cancer. However, nobody has stimulated hypoxia in a 3D microenvironment. Here, we developed a fundamental technology to create hydrogel materials that can serve as 3D hypoxic microenvironments. The HI hydrogels are formed via oxygen consumption in a laccase-mediated...

Published: 6/27/2024 | Inventor(s): Kyung Min Park, Sharon Gerecht

Keywords(s): Bioreactor-based Manufacturing, Disease Indication, Implanted Device, Implants, Industrial Manufacturing, Manufacturing Method, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Industrial Tech, Technology Classifications > Medical Devices, Technology Classifications > Engineering Tech > Industrial Manufacturing

An economical and environmentally-sound process for enhanced extraction and purification of oils from wet microalgal biomass using high-pressure CO2 as a solute

C11204: An Economically and Environmentally-sound Process for Enhanced Extraction and Purification of Oils from Wet Microalgal Biomass Using High Pressure CO2 as a SoluteValue Proposition: • Addresses a major need in new methods for efficient biofuel production. • Fundamentally different from conventional supercritical CO2 extraction. •...

Published: 6/27/2024 | Inventor(s): Michael Betenbaugh, George Oyler, Julian Rosenberg, Marc Donohue

Keywords(s): Bioreactor-based Manufacturing, Industrial Manufacturing, Manufacturing Method

Category(s): Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Industrial Manufacturing

Engineering Intracellular Sialylation Pathways

C01426: Engineering Intracellular Sialylation PathwaysValue Proposition: Manipulating carbohydrate processing pathways in insect and other eukaryotic cells so that the cells produce complex sialylated glycoproteins is useful for enhancing the value of heterologous expression systems and increasing the application of heterologous cell expression products...

Published: 6/27/2024 | Inventor(s): Timothy Coleman, Don Jarvis, Yuan Lee, Shawn Lawrence, Michael Betenbaugh

Keywords(s): Bioreactor-based Manufacturing, Cell Signaling, Discovery/Research Tools, Glycoproteins, Industrial Manufacturing, Manufacturing Method, Molecular Switches/Receptors, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Technology Classifications > Industrial Tech, Technology Classifications > Research Tools, Technology Classifications > Engineering Tech > Industrial Manufacturing