Search Results - michael+betenbaugh

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Peptide-Based Antifouling Membrane Filtration Systems for Continuous Protein Harvesting

Unmet NeedCell and cell-derived therapies, including protein and antibodies, are being developed as a new and promising class of medicine. These kinds of therapeutics require a nuanced and precise manufacturing process, including bioreactors and filtration systems that can reliably obtain large quantities of the desired product consistently [8, 9]....

Published: 6/28/2024 | Inventor(s): Honggang Cui, Boran Sun, Michael Betenbaugh, David Stern

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Engineered Fibroblasts as Cell Therapy to Treat Cancer via Tumor Stroma Stabilization

Unmet Need / Invention Novelty: Carcinoma associated fibroblasts (CAFs) are associated with the development of high-grade malignancies of poor prognoses, as they facilitate cancer invasion and hinder anti-cancer drug delivery. In order to improve the long-term survival rate of pre-metastatic cancer patients, we report genetically engineered fibroblasts...

Published: 6/28/2024 | Inventor(s): Yun Chen, Wei-Hung Jung, Michael Betenbaugh, Franck Housseau

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Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Engineering post-translational processing for native-like BChE production in CHO cells

C11380: Novel Biological Countermeasure Against Toxic Nerve AgentsNovelty: The technology comprises a novel recombinant butyrlcholinesterase (BChE) protein that is long lived and has the same properties as those of plasma derived natural BChE protein.Value Proposition: Currently, the short lived recombinant BChE protein and its other inferior properties...

Published: 6/27/2024 | Inventor(s): Michael Betenbaugh

Keywords(s): Biologics, Drug Delivery Vehicle, Polymers, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

An economical and environmentally-sound process for enhanced extraction and purification of oils from wet microalgal biomass using high-pressure CO2 as a solute

C11204: An Economically and Environmentally-sound Process for Enhanced Extraction and Purification of Oils from Wet Microalgal Biomass Using High Pressure CO2 as a SoluteValue Proposition: • Addresses a major need in new methods for efficient biofuel production. • Fundamentally different from conventional supercritical CO2 extraction. •...

Published: 6/27/2024 | Inventor(s): Michael Betenbaugh, George Oyler, Julian Rosenberg, Marc Donohue

Keywords(s): Bioreactor-based Manufacturing, Industrial Manufacturing, Manufacturing Method

Category(s): Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Industrial Manufacturing

Mammalian Anti-apoptotic Gene Promotes Stress Tolerance in Green Microalgae for Increased Cell Viability and Biomass Production During Cultivation

C10920: Genetically Engineered Algae to Increase Cell Viability and Biomass ProductionValue Proposition: • Increases cell viability and biomass production. • High-level expression of recombinant proteins. • Addresses a major need in new biofuel sources. • Proprietary constructs are available. Technical Details: In certain...

Published: 6/27/2024 | Inventor(s): Julian Rosenberg, George Oyler, Michael Betenbaugh

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Promotor, Research Reagent

Category(s): Technology Classifications > Industrial Tech > Materials, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Industrial Tech, Technology Classifications > Research Tools, Technology Classifications > Engineering Tech > Materials

Engineering Intracellular Sialylation Pathways

C01426: Engineering Intracellular Sialylation PathwaysValue Proposition: Manipulating carbohydrate processing pathways in insect and other eukaryotic cells so that the cells produce complex sialylated glycoproteins is useful for enhancing the value of heterologous expression systems and increasing the application of heterologous cell expression products...

Published: 6/27/2024 | Inventor(s): Timothy Coleman, Don Jarvis, Yuan Lee, Shawn Lawrence, Michael Betenbaugh

Keywords(s): Bioreactor-based Manufacturing, Cell Signaling, Discovery/Research Tools, Glycoproteins, Industrial Manufacturing, Manufacturing Method, Molecular Switches/Receptors, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Technology Classifications > Industrial Tech, Technology Classifications > Research Tools, Technology Classifications > Engineering Tech > Industrial Manufacturing