Search Results - yun+chen

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Treatment of mucus-related diseases via modulation of mechanosignaling pathways activated by high mucus viscosity

Value Proposition· Restoration of pro-repair cell dynamics: targets the high mucus viscosity that drives exacerbation of muco-obstructive lung diseases (COPD, CF, IPF)· Addresses biophysical mechanism of disease development: disrupts the counter-reparative mechanosignaling pathway activated by elevated mucus viscosity· Cell type-specific...

Published: 4/3/2026 | Inventor(s): Yun Chen, Matthew Pittman, Sergey Plotnikov

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Category(s): Technology Classifications > Therapeutic Modalities

Cell Therapy for the Treatment and Prevention of Carcinoma and Tumor Progression

Unmet Need / Invention Novelty: Carcinoma associated fibroblasts (CAFs) are associated with the development of high-grade malignancies of poor prognoses, as they facilitate cancer invasion and hinder anti-cancer drug delivery. In order to improve the long-term survival rate of pre-metastatic cancer patients, we report genetically engineered fibroblasts...

Published: 4/3/2026 | Inventor(s): Yun Chen, Wei-Hung Jung, Michael Betenbaugh, Franck Housseau

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Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Oncology > Colorectal Cancer

Force-dependent drug release system for enhanced cancer treatment

Unmet NeedEach year, 650,000 people receive chemotherapy in an outpatient oncology clinic in the US. This technology is a development of force-dependent drug release system for the enhancement of selective killing and minimization of adverse effects to cancer treatments. Current chemotherapies suffer drawback: normal cells might be and are often inadvertently...

Published: 4/3/2026 | Inventor(s): Yun Chen, Seungman Park

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Device, Implanted Device, Implants, Protein, Therapeutic Devices, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Proteins, Clinical and Disease Specializations > Oncology