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Peptide-Based Antifouling Membrane Filtration Systems for Continuous Protein Harvesting

Unmet NeedCell and cell-derived therapies, including protein and antibodies, are being developed as a new and promising class of medicine. These kinds of therapeutics require a nuanced and precise manufacturing process, including bioreactors and filtration systems that can reliably obtain large quantities of the desired product consistently [8, 9]....

Published: 3/14/2025 | Inventor(s): Honggang Cui, Boran Sun, Michael Betenbaugh, David Stern

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Polymers for Binding-Triggered Antibody Precipitation and Purification

Value PropositionResults in >97% precipitation yield, >88% elution yield of mAbsSimplified molecular design compared to elastin-like polypeptide (ELP)-based materialsDoes not need additional salt to achieve mAb precipitation and recoveryTechnology DescriptionResearchers at Johns Hopkins have developed a peptide-based platform technology using...

Published: 3/14/2025 | Inventor(s): Honggang Cui, Yi Li, David Stern, XuanKuo Xu, Lye Lin Lock, Jason Mills, Sanchayita Ghose, Zheng Jian Li

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Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies