Search Results - yeast+model

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A CRISPR-based yeast two-hybrid system for investigating RNA-protein interaction

Unmet Need: DNA-sequencing technology has led to the development of many powerful techniques, such as RIP-seq and CLIP-seq, which can be used to identify many RNAs bound by a protein of interest, however, few protocols exist for identifying the proteins bound to a particular RNA. Most available techniques involve RNA pull-down followed by protein identification...

Published: 9/26/2024 | Inventor(s): David Zappulla, Evan Hass

Keywords(s): Analytical Method, Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Target-based Screening Tool, Yeast Model

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics

SUB280 Yeast with Hygromycin Marker at LEU2

An Ubiquitin Expressed Yeast Strain at LEU2 JHU REF: [C12803]Invention Novelty: A genetically engineered single ubiquitin expressed Yeast strain at (leucine) LEU2 to serve as an in vivo model for the discovery of ubiquitin linkage roles in subcellular signal pathways Value Proposition: Unique Polyubiquitination (polyUb) linkage combinations serve essential...

Published: 9/26/2024 | Inventor(s): Eric Cooper, Robert Cohen

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Yeast Model

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Yeast Model

Super Two Micron Plasmid Vectors for Yeast

Value Proposition: A major limitation to efficient production of proteins in yeast has been vector systems that consistently yield large amounts of recombinant protein. Whereas yields of 20-50% of total protein can readily be attained in bacterial systems, yeast systems typically yield 1-2%, and only occasionally as high as 5%. Yet yeast is highly desirable...

Published: 9/26/2024 | Inventor(s): Jef Boeke

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Plasmid, Research Reagent, Yeast Model

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Suppressors of p53 Cancer Mutations & Genetic Assays and Strains using Human TP53

C09941: Suppressors of p53 Cancer Mutations & Genetic Assays and Strains using Human TP53 Technical Details: The technology concerns the identification of second-site suppressor mutations that can act as Aglobal suppressors@ to overcome the deleterious effects of common p53 cancer mutations responsible for more than 50% of all cancers. Such suppressor...

Published: 9/26/2024 | Inventor(s): Rainer Brachmann, Jef Boeke

Keywords(s): Basic Research Biomarker, Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Oncogene, Research Reagent, Yeast Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

Wild-Type Amyloid Precursor Protein Yeast Artificial Chromosome Transgenic Line Py8.9

C04586: Wild-Type Amyloid Precursor Protein Yeast Artificial Chromosome Transgenic Line Py8.9 Technical Details: Researchers at Johns Hopkins and Case Western Reserve University have generated a transgenic mouse (Py8.9) line that expresses the wild-type human Amyloid Precursor Protein (APP). This mouse was generated through the insertion of a Yeast...

Published: 9/26/2024 | Inventor(s): Bruce Lamb, John Gearhart

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines, Yeast Model

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

pNB1 + pNB3

C04005: pNB1 + pNB3 Technical Details: These molecular biology research tools are recombinant yeast plasmids that were designed for use with an in vitro Tn7 transposition systemLooking for Partners: Genome analysis, characterization and manipulation.

Published: 9/26/2024 | Inventor(s): Nurjana Bachman, Jef Boeke

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Plasmid, Research Reagent, Yeast Model

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools