Search Results - jef+boeke

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A Mouse Monoclonal Antibody Against Human LINE-1 ORF1p

Invention Novelty:Johns Hopkins researchers have developed a monoclonal antibody against the cancer-associated protein LINE-1 ORF1p. Technical Overview:There is great unmet need for a method of easily and broadly screening for cancer. Biomarkers, one of the major tools used in cancer screening, are usually specific for one cancer type, making testing...

Published: 3/13/2025 | Inventor(s): Kathleen Burns, Jef Boeke, Nemanja Rodic, Martin Taylor

Keywords(s): Antibodies, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Monoclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools

Super Two Micron Plasmid Vectors for Yeast

Value Proposition: A major limitation to efficient production of proteins in yeast has been vector systems that consistently yield large amounts of recombinant protein. Whereas yields of 20-50% of total protein can readily be attained in bacterial systems, yeast systems typically yield 1-2%, and only occasionally as high as 5%. Yet yeast is highly desirable...

Published: 3/13/2025 | Inventor(s): Jef Boeke

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Plasmid, Research Reagent, Yeast Model

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Suppressors of p53 Cancer Mutations & Genetic Assays and Strains using Human TP53

C09941: Suppressors of p53 Cancer Mutations & Genetic Assays and Strains using Human TP53 Technical Details: The technology concerns the identification of second-site suppressor mutations that can act as Aglobal suppressors@ to overcome the deleterious effects of common p53 cancer mutations responsible for more than 50% of all cancers. Such suppressor...

Published: 3/13/2025 | Inventor(s): Rainer Brachmann, Jef Boeke

Keywords(s): Basic Research Biomarker, Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Oncogene, Research Reagent, Yeast Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

Histone Mutant Plasmid Collections

C05076: Histone Mutant Plasmid Collections Technical Details: Epigenetics, the study of stable alterations in gene expression that arise during development and cell proliferation, is a popular area of modern bioscience. The epigenetic context in which genes are expressed is important for understanding normal phenotypic variation and disease. DNA...

Published: 3/13/2025 | Inventor(s): Jef Boeke

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Instrument System for Managing and Cherry Picking Microorganism Collections

Value Proposition: Currently, no commercial liquid handler exists that can transfer biomaterials from freezer storage to a destination plate for subsequent experimental manipulation. The novel retrieval module could be integrated to various models of robotic freezers and liquid handling systems and increase throughput while eliminating contamination...

Published: 3/13/2025 | Inventor(s): Shunyou Long, Min Li, Heng Zhu, Jef Boeke

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Research Tools

Method for Finding Mutations Caused by the Insertion of Repeated DNAs

C04260: Method for Finding Mutations Caused by the Insertion of Repeated DNAsNovelty: This invention provides a novel method for identifying repeat insertion mutations, useful for identifying or classifying genetic diseases, and mapping complex traits controlled by repeat insertions.Value Proposition: Currently available human mutation detection methods,...

Published: 3/13/2025 | Inventor(s): Jef Boeke

Keywords(s): Cancers, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic System, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Neurology

Synthetic mammalian retrotransposon gene

C04212: Synthetic mammalian retrotransposon geneValue Proposition: • Synthetic retrotransposable element that can integrate into the genome • Exhibits a higher level of expression relative to natural L1 retrotransposon gene • A new method for delivering desired DNA to humans and other mammals, including gene therapies • Improves...

Published: 3/13/2025 | Inventor(s): Jeffrey Han, Jef Boeke

Keywords(s): Biologics, Gene Therapy, Nucleic Acid, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities

pNB1 + pNB3

C04005: pNB1 + pNB3 Technical Details: These molecular biology research tools are recombinant yeast plasmids that were designed for use with an in vitro Tn7 transposition systemLooking for Partners: Genome analysis, characterization and manipulation.

Published: 3/13/2025 | Inventor(s): Nurjana Bachman, Jef Boeke

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Plasmid, Research Reagent, Yeast Model

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools