Search Results - oncogene

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TC-1 P3 (A15)

Novelty:A cell line comprising the TC-1 P3 subclone to serve as an immune resistant tumor model for cancer immunotherapy research.Value Proposition:Many human tumors demonstrate downregulation of MHC class I molecule expression as a means of immune evasion. Thus, the development of a suitable tumor model with downregulated MHC class I expression is...

Published: 7/4/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Autoimmune Diseases, Basic Research Biomarker, Cancers, Cell Lines, Cloning Reagents, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Inflammatory Disorders, Mouse Cell Lines, Oncogene, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology

Suppressors of p53 Cancer Mutations & Genetic Assays and Strains using Human TP53

C09941: Suppressors of p53 Cancer Mutations & Genetic Assays and Strains using Human TP53 Technical Details: The technology concerns the identification of second-site suppressor mutations that can act as Aglobal suppressors@ to overcome the deleterious effects of common p53 cancer mutations responsible for more than 50% of all cancers. Such suppressor...

Published: 7/4/2024 | Inventor(s): Rainer Brachmann, Jef Boeke

Keywords(s): Basic Research Biomarker, Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Oncogene, Research Reagent, Yeast Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

HEYL, A Novel Oncogene

C04936: HEYL, A Novel Oncogene Technical Details: TGF-beta signal transduction is a primary tumor suppression pathway in breast cancer. Many breast cancer cells gain mechanisms to counteract the TGF-beta inhibitory effect but the mechanisms have remained elusive. Recently, scientists at Johns Hopkins University have identified a new oncogene that appears...

Published: 7/4/2024 | Inventor(s): Liangfeng Han, Saraswati Sukumar

Keywords(s): Cloning Reagents, Discovery/Research Tools, Oncogene, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

A Fast, Cell-based, High-throughput Assay for the Identification of Compounds with DNA-interstrand Crosslinking Capability

C04868: A Fast, Cell-based, High-throughput Assay for the Identification of Compounds with DNA-interstrand Crosslinking Capability Technical Details: Using somatic cell gene targeting, isogenic cell clones were created from the colorectal cancer cell line RKO. Each KO cell line differed only in the allelic status of one Fanconi Anemia (FA) gene,...

Published: 7/4/2024 | Inventor(s): Eike Gallmeier, Scott Kern

Keywords(s): Cloning Reagents, Discovery/Research Tools, Oncogene, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

Identification of P53-activating Compounds for Cancer Research and Therapy

C03857: Cell line to identify inhibitors of p53 Technical Details: An exciting, new invention from the laboratory of Dr. Scott Kern at The Johns Hopkins University School of Medicine for the identification of p53 activating compounds that would be of interest to In Vitro Technologies. The status of p53 varies among human tumors and has been associated...

Published: 7/4/2024 | Inventor(s): Taylor Riall, Scott Kern

Keywords(s): Basic Research Biomarker, Biomarker, Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Oncogene, Pharmakodynamic Biomarker, Research Reagent, Single, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities