Search Results - t.c.+wu

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Albumin-Flt3L Fusion Protein to Enhance Anti-Tumor Immunity and Antigen-specific T-cell Cytotoxicity

Unmet Need: Active immunotherapy, such as anti-PD-1/PD-L1 and anti-CTLA-4 checkpoint blockage, involves the administration of molecules to mobilize host immune cells to recognize and kill tumors. Proper presentation of tumor antigens through antigen presenting cells is a prerequisite to elicit a potent immune response. Current strategies enhance antigen...

Published: 6/20/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung, Brandon Lam

Keywords(s): Biologics, Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Research Instrument, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Immunology, Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets

TC-1/A2

TITLE: TC-1/A2 cell lineCASE NUMBER: C04953TECHNOLOGYJHU Scientists characterized the ability of DNA-encoding calreticulin linked to DNA-encoding E7 antigen to generate HLA-A2-restricted E7-specific CD8+ T-cell responses in HLA-A2 (AAD) transgenic mice, as well as antitumor effects against an E7+ HLA-A2+ tumor cell line, TC-1/A2.TECHNICAL DETAILSScientists...

Published: 6/20/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Utility of N501Y + 19del + D614G Variant SARS-CoV-2 Pseudoviruses for COVID-19 Mouse Modeling

Unmet Need: Globally, there are more than 213,000,000 confirmed cases of COVID-19, including more than 4,448,000 deaths reported to the World Health Organization (WHO) (WHO, 2021) by August 25th, 2021. The number of cases and deaths increase each day. Various animal models have been used to study COVID-19 with varying susceptibility due to species-specific...

Published: 6/21/2024 | Inventor(s): Chien-Fu Hung, Brandon Lam, Ya Chea Tsai, T.c. Wu

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Technology Classifications > Research Tools > Viruses

Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency

Unmet Need: DNA vaccine technology is a desirable antiviral and cancer immunotherapeutic strategy for its simple design and cost-effective implementation. However, current DNA vaccine programs are hindered by poor immunogenicity. Technical Details: Johns Hopkins researchers have designed a novel fusion construct to enhance immunogenicity to DNA vaccines....

Published: 6/20/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Cancers, Combination, Disease Indication, Immunotherapy/ Immunotherapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities

Single-Molecule Analysis by Shape (SMASH) as an Ultra-sensitive Blood Test for Cancer Biomarkers

Unmet Need / Invention Novelty: Early cancer detection leads to increased survival rates in patients. However, current biomarker assays to detect circulating tumor DNA and proteins lack the sensitivity needed to detect the earliest stages of cancer development.Technical Details: Johns Hopkins researchers have developed a novel assay to detect circulating...

Published: 6/20/2024 | Inventor(s): Chien-Fu Hung, Chih-Ping Mao, Shih-Chin Wang, Jie Xiao, T.c. Wu

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old)

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics

Annexin V-HPV E7 Fusion Protein for Cancer Treatment

Unmet needHuman papillomavirus (HPV) causes the majority of cases of cervical cancer, which affects approximately 500,000 women worldwide each year. Additionally, HPV has been associated with other cancers including penile, vaginal, vulvar, anal, and head and neck cancers. Currently, there are limited treatment options for patients with advanced cervical...

Published: 6/20/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung, Tae Heung Kang

Keywords(s): Biomarker, Cancers, Cervical Cancer, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Oncology > Cervical Cancer, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics > Biomarkers

TC-1 (Po)

C03436: TC-1 (Po) Technical Details:This cell line "was developed to circumvent the confounding issue of negatively selecting nonessential tumor markers in cancer vaccine experiments. Primary lung epithelial cells from C57BL/6 mice were immortalized with HPV-16 E6 and E7 and then transformed with the activated ras oncogene. This transformation...

Published: 6/20/2024 | Inventor(s): T.c. Wu

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Mouse Cell Lines, Other Virus, Research Reagent, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses

HPV-16 H-2 Db Restricted E7 Peptide (aa 49-57)-specific CD8+ T Cell Line

UNMET NEEDHuman papillomaviruses, particularly HPV-16, are associated with most cervical cancers and their precursors. E7 is an oncogenic HPV protein that is expressed in most HPV-positive cervical carcinomas and plays an important role in the initiation and maintenance of cellular transformation. Accordingly, vaccines targeting the E7 protein appear...

Published: 6/20/2024 | Inventor(s): T.c. Wu

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Research Tool, Infectious Diseases, Mouse Cell Lines, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Generation of HPV-16 H-2 Kb-restricted E6 Peptide (aa 48-57)-specific CD8+ T Cell Line

ABSTRACT The HPV-16 E6-specific CD8+ T cell line is generated by vaccinating six to eight week old female C57BL/6 (H2-Kb) mice with 2ug of pcDNA3-CRT/E6 using a helium-driven gene gun. Mice received two boosts with the same regimen 1 and 2 weeks later. The resulted splenocytes were harvested, stimulated with irradiated TC-1 tumor cells in the presence...

Published: 6/20/2024 | Inventor(s): T.c. Wu

Luciferase-expressing HPV-16 H-2 Kb Restricted E7 Peptide (aa 49-57)-specific CD8+ T Cell (E7T-LUC) Line

Unmet Need:A significant challenge in determining the response to Adoptive T cell Transfer (ACT) therapy is the difficulty in assessing the trafficking of antigen specific T cells as well as the therapeutic effect against tumors in vivo without killing the mice. Understanding of the trafficking of antigen-specific CD8+ T cells in vivo will provide insight...

Published: 6/20/2024 | Inventor(s): T.c. Wu

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

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