Search Results - chih-ping+mao

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Single-Molecule Analysis by Shape (SMASH) as an Ultra-sensitive Blood Test for Cancer Biomarkers

Unmet Need / Invention Novelty: Early cancer detection leads to increased survival rates in patients. However, current biomarker assays to detect circulating tumor DNA and proteins lack the sensitivity needed to detect the earliest stages of cancer development.Technical Details: Johns Hopkins researchers have developed a novel assay to detect circulating...

Published: 9/26/2024 | Inventor(s): Chien-Fu Hung, Chih-Ping Mao, Shih-Chin Wang, Jie Xiao, T.c. Wu

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old)

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics

Early Cancer Detection by Single-molecule Imaging of Nucleocytoplasmic Tumor-specific Proteins in the Peripheral Circulation

Unmet Need / Invention Novelty: Due to lack of effective early detection modalities, ovarian and pancreatic cancers are rarely found until the disease has progressed and hence are highly lethal. To overcome these limitations we report an ultra-sensitive microfluidic chip designed to bind and digitally quantify tumor-derived cancer proteins for an early...

Published: 9/26/2024 | Inventor(s): T.c. Wu, Chih-Ping Mao, Shih-Chin Wang, Jie Xiao, Chien-Fu Hung

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Programmed Self-assembly of a Peptide-MHC Dynamic Anchor for Antigen-specific Immune Modulation

Unmet Need: Use of T-cells in the eradication of diseases has been limited by the inability to produce or enhance activation of desired T-cell populations to an antigen of interest, ultimately leading to disease progression. Technical Details: Johns Hopkins researchers have developed novel fusion constructs that produce and/or enhance T-cell activation...

Published: 9/26/2024 | Inventor(s): Chih-Ping Mao, Chien-Fu Hung, T.c. Wu

Keywords(s): Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities