Search Results - chien-fu+hung

18 Results

Sort By:

Albumin-Flt3L Fusion Protein to Enhance Anti-Tumor Immunity and Antigen-specific T-cell Cytotoxicity

Unmet Need: Active immunotherapy, such as anti-PD-1/PD-L1 and anti-CTLA-4 checkpoint blockage, involves the administration of molecules to mobilize host immune cells to recognize and kill tumors. Proper presentation of tumor antigens through antigen presenting cells is a prerequisite to elicit a potent immune response. Current strategies enhance antigen...

Published: 6/20/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung, Brandon Lam

Keywords(s): Biologics, Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Research Instrument, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Immunology, Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets

TC-1/A2

TITLE: TC-1/A2 cell lineCASE NUMBER: C04953TECHNOLOGYJHU Scientists characterized the ability of DNA-encoding calreticulin linked to DNA-encoding E7 antigen to generate HLA-A2-restricted E7-specific CD8+ T-cell responses in HLA-A2 (AAD) transgenic mice, as well as antitumor effects against an E7+ HLA-A2+ tumor cell line, TC-1/A2.TECHNICAL DETAILSScientists...

Published: 6/20/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Utility of N501Y + 19del + D614G Variant SARS-CoV-2 Pseudoviruses for COVID-19 Mouse Modeling

Unmet Need: Globally, there are more than 213,000,000 confirmed cases of COVID-19, including more than 4,448,000 deaths reported to the World Health Organization (WHO) (WHO, 2021) by August 25th, 2021. The number of cases and deaths increase each day. Various animal models have been used to study COVID-19 with varying susceptibility due to species-specific...

Published: 6/21/2024 | Inventor(s): Chien-Fu Hung, Brandon Lam, Ya Chea Tsai, T.c. Wu

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Covid-19, Technology Classifications > Research Tools > Viruses

Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency

Unmet Need: DNA vaccine technology is a desirable antiviral and cancer immunotherapeutic strategy for its simple design and cost-effective implementation. However, current DNA vaccine programs are hindered by poor immunogenicity. Technical Details: Johns Hopkins researchers have designed a novel fusion construct to enhance immunogenicity to DNA vaccines....

Published: 6/20/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Cancers, Combination, Disease Indication, Immunotherapy/ Immunotherapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities

Single-Molecule Analysis by Shape (SMASH) as an Ultra-sensitive Blood Test for Cancer Biomarkers

Unmet Need / Invention Novelty: Early cancer detection leads to increased survival rates in patients. However, current biomarker assays to detect circulating tumor DNA and proteins lack the sensitivity needed to detect the earliest stages of cancer development.Technical Details: Johns Hopkins researchers have developed a novel assay to detect circulating...

Published: 6/20/2024 | Inventor(s): Chien-Fu Hung, Chih-Ping Mao, Shih-Chin Wang, Jie Xiao, T.c. Wu

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old)

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics

Annexin V-HPV E7 Fusion Protein for Cancer Treatment

Unmet needHuman papillomavirus (HPV) causes the majority of cases of cervical cancer, which affects approximately 500,000 women worldwide each year. Additionally, HPV has been associated with other cancers including penile, vaginal, vulvar, anal, and head and neck cancers. Currently, there are limited treatment options for patients with advanced cervical...

Published: 6/20/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung, Tae Heung Kang

Keywords(s): Biomarker, Cancers, Cervical Cancer, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Oncology > Cervical Cancer, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics > Biomarkers

Early Cancer Detection by Single-molecule Imaging of Nucleocytoplasmic Tumor-specific Proteins in the Peripheral Circulation

Unmet Need / Invention Novelty: Due to lack of effective early detection modalities, ovarian and pancreatic cancers are rarely found until the disease has progressed and hence are highly lethal. To overcome these limitations we report an ultra-sensitive microfluidic chip designed to bind and digitally quantify tumor-derived cancer proteins for an early...

Published: 6/20/2024 | Inventor(s): T.c. Wu, Chih-Ping Mao, Shih-Chin Wang, Jie Xiao, Chien-Fu Hung

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Targeted delivery of antigenic CTL peptide to tumor loci by Annexin V renders tumor cells susceptible to adaptive CD8+ cell immunity

Antigen-specific immunotherapy represents a promising methodology to control tumors because it can stimulate the immune system to specifically target and eliminate tumor cells. To overcome the challenge of immune tolerance, which is common to immunotherapy, we generated a novel chimeric protein to selectively coat tumor cells with a foreign immunogenic...

Published: 6/20/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Antigens, Biologics, Cancers, Chemotherapy/Immunotherapy, Combination, Disease Indication, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Programmed Self-assembly of a Peptide-MHC Dynamic Anchor for Antigen-specific Immune Modulation

Unmet Need: Use of T-cells in the eradication of diseases has been limited by the inability to produce or enhance activation of desired T-cell populations to an antigen of interest, ultimately leading to disease progression. Technical Details: Johns Hopkins researchers have developed novel fusion constructs that produce and/or enhance T-cell activation...

Published: 6/20/2024 | Inventor(s): Chih-Ping Mao, Chien-Fu Hung, T.c. Wu

Keywords(s): Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities

Creation of Murine Ovarian Cancer Cell Line Suitable for Non-Invasive Imaging

Trackable Murine Ovarian Cancer Cell LineJHU REF: [C12340]Invention novelty: This tangible material is a transgenic murine ovarian cancer cell line expressing luciferase for non-invasive monitoring of tumor load in a mouse bearing this cell line. Value Proposition: There is a need for cancer cell lines that can be monitored/detected non-invasively....

Published: 6/20/2024 | Inventor(s): T.c. Wu, Chien-Fu Hung

Keywords(s): Animal Imaging Tools, Assay, Basic Research Biomarker, Cancers, Cell Lines, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Ovarian Cancer

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Technology Classifications > Diagnostics > Diagnostic Imaging

1 2