Search Results - eike+gallmeier

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C10131: MKK4/MAP2K4 KO Lines for Drug DiscoveryValue Proposition: MKK4 (JNKK1, MAP2K4, and SEK1), a dual-specificity kinase gene on chromosome 17p11, is a tumor suppressor gene that is mutated in a subset of most tumor types. MKK4 protein is activated by several kinases, and active MKK4 cooperates with MKK7 to phosphorylate and thereby activate Jun...

Published: 7/4/2024 | Inventor(s): Steven Cunningham, Eike Gallmeier, Scott Kern

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

A Functional Assay Distinguishing Pathogenic and Nonpathogenic Variant Alleles of the BRCA2 Gene

C05150: Identification of Pathological BRCA2 Alleles and Variant-Specific Drug ScreeningNovelty: A functional assay to identify genetic variants of tumor suppressor genes that may be associated with cancer risk, applicable for personalized therapy and genome-specific drug screening.Value Proposition: The formation of human cancers is often associated...

Published: 7/4/2024 | Inventor(s): Eike Gallmeier, Thomas Hucl, Scott Kern

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Diagnostic Biomarkers

A Fast, Cell-based, High-throughput Assay for the Identification of Compounds with DNA-interstrand Crosslinking Capability

C04868: A Fast, Cell-based, High-throughput Assay for the Identification of Compounds with DNA-interstrand Crosslinking Capability Technical Details: Using somatic cell gene targeting, isogenic cell clones were created from the colorectal cancer cell line RKO. Each KO cell line differed only in the allelic status of one Fanconi Anemia (FA) gene,...

Published: 7/4/2024 | Inventor(s): Eike Gallmeier, Scott Kern

Keywords(s): Cloning Reagents, Discovery/Research Tools, Oncogene, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools