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C05188: BRCA2 KO Lines for Drug Discovery Technical Details: BRACA2 is a DNA repair gene. Mutations in BRACA2 cause an inherited risk of breast, ovarian and pancreatic cancers. The cancer cell lines are engineered to lack BRACA2 and are useful screening tools for chemotherapeutic or chemopreventative agentsLooking for Partners: The BRACA2 KO cell...

Published: 9/26/2024 | Inventor(s): Thomas Hucl, Scott Kern

Keywords(s): Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Ovarian Cancer, Pancreatic Cancer, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines

A Functional Assay Distinguishing Pathogenic and Nonpathogenic Variant Alleles of the BRCA2 Gene

C05150: Identification of Pathological BRCA2 Alleles and Variant-Specific Drug ScreeningNovelty: A functional assay to identify genetic variants of tumor suppressor genes that may be associated with cancer risk, applicable for personalized therapy and genome-specific drug screening.Value Proposition: The formation of human cancers is often associated...

Published: 9/26/2024 | Inventor(s): Eike Gallmeier, Thomas Hucl, Scott Kern

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Diagnostic Biomarkers