Search Results - risk+stratification

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Global DNA Hypomethylation as Biomarker for Clinical Detection, Inflammation Severity, and Disease Progression in Gastric Cancer

C11444: Novel Biomarker for Diagnosis of Gastric CancerNovelty: The reported technology identifies a novel biomarker for clinical detection, inflammation severity, and disease progression in gastric cancer.Value Proposition: The technology outlined is a diagnostic technique to detect a biomarker known to play a major role in gastric carcinogenesis....

Published: 9/26/2024 | Inventor(s): David Sidransky, Rafael Guerrero-Preston

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Gastric Cancer, In Vitro Diagnostics, Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Gastric Cancer

Genomic Drivers of Response to Immunotherapy

Unmet NeedTumor mutational burden (TMB) is a measurement of mutations carried by tumor cells and is but one emerging biomarker for some types of cancer, including non-small cell lung cancer. Currently, there is a lack of standardization for tumor mutational burden calculation and reporting. Different tests may report different measurements, and since...

Published: 9/27/2024 | Inventor(s): Valsamo Anagnostou, Victor Velculescu, Noushin Niknafs Kermani

Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics (Old), Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Computers, Electronics & Software > Algorithms

Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy

Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...

Published: 9/26/2024 | Inventor(s): Ami Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki Laiho

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Risk Stratification, Scleroderma, Skin Disorders, Skin Fibrosis, Therapeutic Matter, Therapeutic Substance, Therapeutics

RNA In Situ Hybridization Assay (RISH) for the Detection of Prostate Cancer Cells in Urine

Unmet NeedProstate cancer is one of the most commonly diagnosed cancers in the male population; roughly one out of ten men will be diagnosed at some point in their lives. Efficient screening and accurate diagnosis is a public health imperative due to the large potential patient population. Prostate cancer is usually diagnosed following an abnormal physical...

Published: 9/26/2024 | Inventor(s): Jun Luo, Christian Pavlovich, William Isaacs, Jillian Eskra

Keywords(s): Assay, Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prostate Cancer, Risk Stratification

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Elevated CCL19 after Completion of Therapy for Acute Lyme Disease Identifies Patients at Risk for Development of Post-treatment Lyme Disease Syndrome Who Will Benefit from Further Antibiotic Therapy

Unmet Need: Lyme disease is the most common tick-borne disease in temperate regions that can lead to persistent and life-altering symptoms including arthritis and neurological dysfunction. Even when caught and treated early, approximately 10-20% of patients have persistent symptoms lasting 6+ months known as posttreatment Lyme disease syndrome (PTLDS)....

Published: 9/26/2024 | Inventor(s): John Aucott, Mark Soloski

Keywords(s): Bacterial Infections, Biomarker, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Lyme Disease, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Lyme Disease, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases

Paternal Sperm DNA Methylation as a Predictive Marker of Autism Risk

Unmet Need:Autism spectrum disorder (ASD), is a complex neurodevelopmental disorder that refers to a range of conditions characterized by challenges with behavior including social skills, communication, and repetitive behaviors, all of which have ranges and severities that are patient specific. Currently, there are no medical tests such as a scan or...

Published: 9/26/2024 | Inventor(s): Andrew Feinberg, Margaret Fallin

Keywords(s): Autism, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics, Methylation, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Autism, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry

PALB2 Gene Mutations Identify Susceptibility to DNA Damaging Agents

PALB2 Gene Mutations Identify Susceptibility to DNA Damaging AgentsJHU Ref #: C10869Unmet NeedPancreatic cancer is predicted to be the second leading cause of cancer-related death by 2030 (Siegel et al., 2020). However, many patients present with advanced disease, and typical broad-spectrum chemotherapeutic treatments are often insufficient. Precision...

Published: 9/26/2024 | Inventor(s): Ralph Hruban, Bert Vogelstein, Kenneth Kinzler, Victor Velculescu, Scott Kern, Sian Jones, Michael Goggins, Manuel Hidalgo, Alison Klein, James Eshleman, Donald Parsons

Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics, Risk Stratification

Category(s): Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Precision Medicine Tools

Using DNA Methylation Markers To Create a Molecular Staging Paradigm for Solid Malignancies and To Predict Cancer Recurrence and Patient Survival

Technology: Currently, cancer recurrence in solid malignancies occurs in many patients after complete curative surgery despite no additional histological evidence of remaining cancer outside the area of resection, especially in the surrounding lymph nodes. It is believed that in patients with recurrent disease, micrometastases reside that are undetectable...

Published: 9/26/2024 | Inventor(s): James Herman, Stephen Baylin, Malcolm Brock

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, In Vitro Diagnostics, Methylation, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics

A Genetic Assay to Determine Prognosis in Polycythemia vera Patients

C12165: Genetic Biomarker Prognostic Screen for Polycythemia Vera PatientsNovelty: The technology is a PCR-based screening assay based on identified genetic biomarkers to determine prognosis in polycythemia vera patients.Value Proposition: Polycythemia vera (PV) is a blood cell disorder complicated by the risk of disease progression into acute myeloid...

Published: 9/26/2024 | Inventor(s): Michael Ochs, Michael Considine, Alison Moliterno, Donna Rowley, Jerry Spivak

Keywords(s): Biomarker, Blood Disorder, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Polycythemia Vera, Polycythemia vera (PV), Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology > Polycythemia Vera, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Hematology

Molecular Signatures of Invasive Cancer Subpopulations

C11851: Assay and molecular signature to identify invasive cancer cell population in tumorsNovelty: This invention is an assay for evaluating the metastatic potential of epithelial cancers, and a molecular signature linked to aggressive and invasive cancer subpopulations.Value Proposition: Inventors have developed an assay to enable stratification of...

Published: 9/26/2024 | Inventor(s): Kevin Cheung, Andrew Ewald

Keywords(s): Assay, Basic Research Biomarker, Biomarker, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Mechanism-of-action Biomarker, Prognostic Biomarker, Risk Stratification, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Epithelial Cancer

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