Search Results - andrew+feinberg

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Methylation Anti-Profiling a Novel Approach to Diagnosing Cancer

Novelty:The disclosed technology is a novel approach to diagnosing cancer, by looking for loss of methylation stability in gene expression instead of searching for specific methylation profiles.Value Proposition:The conventional approach to identifying epigenetic cancer markers is by querying the methylation profiles at specific sites within the DNA....

Published: 6/27/2024 | Inventor(s): Andrew Feinberg, Rafael Irizarry

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

Large-scale Epigenomic Reprogramming Links Anabolic Glucose Metabolism to Distant Metastasis during the Evolution of Pancreatic Cancer Progression

Unmet NeedPancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer death in the western world by 2020. Subclonal populations that emerge and drive metastatic progression of the disease are associated with high mortality rates among patients. Blocking the tumorigenic potential of metastatic sites is key to improving...

Published: 6/27/2024 | Inventor(s): Andrew Feinberg, Xin Li, Christine Iacobuzio-Donahue, Oliver McDonald

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Pancreatic Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer

Paternal Sperm DNA Methylation as a Predictive Marker of Autism Risk

Unmet Need:Autism spectrum disorder (ASD), is a complex neurodevelopmental disorder that refers to a range of conditions characterized by challenges with behavior including social skills, communication, and repetitive behaviors, all of which have ranges and severities that are patient specific. Currently, there are no medical tests such as a scan or...

Published: 6/27/2024 | Inventor(s): Andrew Feinberg, Margaret Fallin

Keywords(s): Autism, Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics, Methylation, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Autism, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry

Novel Screen for Hypermethylated Genes as Biomarkers to Diagnose/ Prognose Colorectal Cancer

C10533: Novel Screen for Hypermethylated Genes as Biomarkers to Diagnose/ Prognose Colorectal CancerValue Proposition: ADVANTAGES • Combination of array-design and computational algorithms makes the assay uniquely efficient for colon cancer diagnostics/prognostics for fast results and shorter time to patient treatment. • Technology requires...

Published: 6/27/2024 | Inventor(s): Rafael Irizarry, Andrew Feinberg

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Disease Indication, Epigenetic, In Vitro Diagnostics, Prognostic Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology