Search Results - james+herman

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Using DNA Methylation Markers To Create a Molecular Staging Paradigm for Solid Malignancies and To Predict Cancer Recurrence and Patient Survival

Technology: Currently, cancer recurrence in solid malignancies occurs in many patients after complete curative surgery despite no additional histological evidence of remaining cancer outside the area of resection, especially in the surrounding lymph nodes. It is believed that in patients with recurrent disease, micrometastases reside that are undetectable...

Published: 6/27/2024 | Inventor(s): James Herman, Stephen Baylin, Malcolm Brock

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Epigenetic, In Vitro Diagnostics, Methylation, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics

Hypermethylation of GATA-4 Transcription Factor Gene in Cancer

Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription factor gene, a GATA-5 transcription factor gene, or both. Methods for ameliorating a cancer by effecting expression of a hypermethylation silenced GATA-4 and/or GATA-5 transcription also are pr...

Published: 6/27/2024 | Inventor(s): Yoshimitsu Akiyama, James Herman, Stephen Baylin

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

Functional Identification of Methylated Cancer Genes

C04028: Functional Identification of Methylated Cancer GenesValue Proposition: • Molecular biomarkers frequently inactivated in primary tumors which displayed clear tumor suppressive activity • Rapid and robust method Technical Details: BACKGROUND Cancer of the esophagus is the eighth most common malignancy and ranks as the sixth most frequent...

Published: 6/27/2024 | Inventor(s): Hiromu Suzuki, Stephen Baylin, James Herman, David Sidransky

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

A Genomic Screen for Genes Upregulated By Demethylation and HDAC Inhibition in Human Colorectal Cancer

C03982: Genomic Screen for Epigenetically Silenced Genes Associated with Colorectal Cancer & Novel Biomarkers for the Detection & Diagnosis of Human Colorectal CancerValue Proposition: Comprehensive biomarker panel for sensitive detection and diagnosis of colon and gastric cancersTechnical Details: BACKGROUND Although cancers generally are considered...

Published: 6/27/2024 | Inventor(s): Hiromu Suzuki, David Sidransky, James Herman, Stephen Baylin

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

SOCS1 Promoter Methylation Identifies a Target for JAK/STAT Activation

C03870: Identification and treatment of cancers with epigenetic silencing of SOCS/CIS genes.Value Proposition: • Methods for early detection, progression, and recurrence of hematological malignancies • Predictive biomarker useful for determining sensitivity to JAK inhibitors • Methods to aid in risk assessment of primary and secondary...

Published: 6/27/2024 | Inventor(s): Curtis Harris, Hirohide Yoshikawa, James Herman

Keywords(s): Biologics, Biomarker, Blood Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gene Therapy, Hematologic Malignancies, In Vitro Diagnostics, In Vitro Research Tool, Multiple Myeloma, Protein, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Clinical and Disease Specializations > Oncology > Multiple Myeloma, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Biologics