Search Results - skin+disorders

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Use of Combination Retinoic Acid and dsRNA Products for Skin Rejuvenation

Unmet NeedGlobally, the anti-aging cosmetic treatment market is projected to grow to $57.5B dollars in 2020. Currently, one of the leading the leading topical ingredients in anti-aging creams for wrinkle reduction is retinoids, which are derivatives of vitamin A. Retinoic acid, the active metabolite of retinoids, has been shown to help repair sun damaged...

Published: 6/28/2024 | Inventor(s): Luis Garza, Dongwon Kim

Keywords(s): Biologics, Chemotherapy/Immunotherapy, Combination, Disease Indication, Nucleic Acid, Skin Disorders, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Wound Healing

Category(s): Technology Classifications > Therapeutic Modalities

A system and methods for the detection of the LD rash and other skin conditions

Unmet NeedThe direct medical costs associated with Lyme disease in the United States are estimated at 2.5 billion dollars annually. Precise diagnosis from laboratory results are only most accurate if taken within a few weeks of being infected. The problem is the symptoms are wide varying and come and go. In addition, one test ELISA (enzyme-linked immunosorbent...

Published: 6/27/2024 | Inventor(s): John Aucott, Philippe Burlina, Neil Joshi, Seth Billings, Elise Ng

Keywords(s): Disease Indication, Image Processing Software, Imaging and Sensing Systems, In Vivo Medical Imaging, Infectious Diseases, Lyme Disease, Pattern Recognition Software, Skin Disorders

Category(s): Clinical and Disease Specializations > Infectious Diseases > Lyme Disease, Clinical and Disease Specializations > Dermatology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Diagnostics > Diagnostic Imaging

Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy

Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...

Published: 6/27/2024 | Inventor(s): Ami Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki Laiho

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Risk Stratification, Scleroderma, Skin Disorders, Skin Fibrosis, Therapeutic Matter, Therapeutic Substance, Therapeutics

Activating Mutations in GNAQ Sensitive to Antibiotic; Novel Molecular Pathway and Treatment Target for Capillary Malformations and Related Syndromes

An unexpected observation while working on developing cell models for these vascular abnormalities generated the following idea: Cells with the capillary malformation/ Sturge-Weber syndrome mutation may be more sensitive to an antibiotic than normal cells. This suggests a particular cell molecular pathway may be signaling abnormally in these cells...

Published: 6/27/2024 | Inventor(s): Anne Comi, Jonathan Pevsner, Zhenhua Huang, Douglas Marchuk

Keywords(s): Biomarker, Disease Indication, Genetic Disorders, Mechanism-of-action Biomarker, Skin Disorders, Sturge-Weber Syndrome, Sturge-Weber Syndrome (SWS), Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology > Sturge-Weber Syndrome, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Dermatology, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Novel biocompatible wireless monitoring device for the prevention of pressure ulcers

INVENTION NOVELTY The Mercury Patch is the first low-cost, wireless wound care product that provides both a monitoring and therapeutic function to help prevent pressure ulcer development within a hospital setting. VALUE PROPOSITION Existing pressure monitoring devices focus on expensive mattress overlay systems, which are cost-prohibitive and impractical...

Published: 6/27/2024 | Inventor(s): Matthew Nojoomi, Kelly Lacob, Madeline Wilson, Alison Wong, Samuel Zschack, Justin Sacks

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Disease Indication, Implanted Device, Implants, Interventional and Surgical Systems, Measurement Tool, Pressure Ulcer, Skin Disorders, Surgical Intervention Method, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology > Pressure Ulcer, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Dermatology, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices

Fibrillin 1 Mutant Mice (W1572C Mutant Strain) and (D1545E Mutant Strain)

TITLE: Fibrillin 1 Mutant Mice (W1572C Mutant strain) and (D1545E Mutant Strain)CASE NUMBER: C13499ABSTRACTFibrillin1 D1545E Mutant StrainThese mice carry a D1545E mutation in the mouse Fbn1 gene and serve as a model of human stiff skin syndrome with increased collagen deposition in the dermis, decreased subcutaneous fat, and circulating anti-nuclear...

Published: 6/27/2024 | Inventor(s): Harry Dietz, Elizabeth Gerber

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Cell Lines, Mouse Model, Skin Disorders, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Dermatology

Diagnostic Test for Sturge-Weber Syndrome (SWS), Klippel-Trenaunay-Weber Syndrome, and Port-Wine Stains (PWSs) Based on Analysis of Gene Mutations and Biological Consequences of the Mutation

Value Proposition:Sturge-Weber syndrome (SWS) is a neurovascular disorder that is often associated with a capillary malformation of the face called a port-wine stain (PWS). SWS is phenotypically related to Klippel-Trenaunay-Weber syndrome (KTWS) which is characterized by a triad of port-wine stain, varicose veins, and bony and soft tissue hypertrophy...

Published: 6/27/2024 | Inventor(s): Douglas Marchuk, Jonathan Pevsner, Anne Comi, Matthew Shirley

Keywords(s): Assay, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Klippel-Trenaunay-Weber Syndrome, Port-Wine Stain, Skin Disorders, Sturge-Weber Syndrome, Sturge-Weber Syndrome (SWS)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Dermatology > Port-Wine Stain, Clinical and Disease Specializations > Dermatology > Sturge-Weber Syndrome, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Genetic Diseases > Klippel-Trenaunay-Weber Syndrome, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

A Transgenic Mouse Model of Atopic Dermatitis, Skin Remodeling, and Atopic March

Value Proposition:JHU scientists have developed an inducible transgenic model in which IL-13 can be expressed in the skin to define the resulting dermal and systemic phenotypes and mechanisms involved. The mice display increased susceptibilty to allergen stimulation in the airways even though the original pathology is in the skin.- Published as: Zheng...

Published: 6/27/2024 | Inventor(s): Zhou Zhu, Tao Zheng

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Skin Disorders, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Dermatology > Atopic Dermatitis, Clinical and Disease Specializations > Dermatology

Precision Three-dimensional Dynamic Thermal Imaging of the Human Body for the Detection of Skin Lesions and other Natural and Abnormal Conditions

C11171: Precision Three-dimensional Dynamic Thermal Imaging of the Human Body for the Detection of Skin Lesions and other Natural and Abnormal Conditions Value Proposition: This technology is a three step process that combines white-light imaging or holography and dynamic infrared imaging with image processing allows accurate three-dimensional dynamic...

Published: 6/27/2024 | Inventor(s): Cila Herman

Keywords(s): Disease Indication, Image Display Software, Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Infrared Imaging, Skin Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

C10069: Treatment of Epidermolysis Bullosa Simplex and Related Diseases

Value Proposition: Advantages: • Uses known natural chemicals to effectively prevent or diminish skin blistering • Represents a safe, effective, and affordable therapy • Has a wider application as the basis for a therapy of keratin-based diseases Technical Details: Epidermolysis bullosa is a disorder characterized by the presence of extremely...

Published: 6/27/2024 | Inventor(s): Michelle Kerns, Pierre Coulombe

Keywords(s): Agonists/Promoters, Disease Indication, Epidermolysis Bullosa Simplex, Non-novel, Predicted Novelty, Skin Disorders, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Genetic Diseases > Epidermolysis Bullosa Simplex, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities