Search Results - antony+rosen

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Antibodies Against CCAR1 Confer Protection Against Cancer

Brief DescriptionStanford and JHU researchers identify an autoantibody response in dermatomyositis patients that is protective of cancer, which may have applications in cancer screening and treatment.Technology Summary Researchers at Stanford University and Johns Hopkins University have identified an antibody that is negatively associated with cancer...

Published: 6/21/2024 | Inventor(s): Antony Rosen, Livia Casciola-Rosen, David Fiorentino

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Profiling of Interferon signaling to diagnose autoimmune disorders

Unmet Need / Invention Novelty: Diagnosing an autoimmune disease using standard laboratory tests is challenging and often requires secondary validation due to high rates of false positives and overlapping biological signatures with other diseases. There is a critical need for an improved method to detect autoimmune disease signatures in tissue collected...

Published: 6/20/2024 | Inventor(s): Livia Casciola-Rosen, Antony Rosen, John Hall

Keywords(s): Autoimmune Diseases, Basic Research Biomarker, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Inflammatory Disorders, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Biomarkers, Clinical and Disease Specializations > Autoimmunity

Detection of ACE2 autoantibodies as markers of severity in COVID-10 patient

Unmet Need / Invention Novelty: SARS-CoV-2 infection can result in severe disease in a subset of infected patients. However, the mechanism underlying severe infection is unknown, hindering patient stratification. There is an unmet need to quickly diagnose and detect markers of severe COVID-19 infection. Technical Details: Researchers at Johns Hopkins...

Published: 6/21/2024 | Inventor(s): Antony Rosen, Livia Casciola-Rosen

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Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases

Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy

Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...

Published: 6/20/2024 | Inventor(s): Ami Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki Laiho

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Risk Stratification, Scleroderma, Skin Disorders, Skin Fibrosis, Therapeutic Matter, Therapeutic Substance, Therapeutics

Autoimmunity-based Peptides as Cancer Vaccines

Autoimmunity-based Peptides as Cancer Vaccines JHU REF: C12807 Invention novelty: This technology uses autoantigen-derived peptides as novel immunotherapy to prevent and treat cancer. Value Proposition: Today, millions of people are living with cancer or have had cancer. Despite significant advances in cancer diagnosis and treatment over the...

Published: 6/20/2024 | Inventor(s): Erika Darrah, Christine Joseph, Kenneth Kinzler, Livia Casciola-Rosen, Nickolas Papadopoulos, Ami Shah, Antony Rosen, Bert Vogelstein

Keywords(s): Antigens, Biologics, Cancers, Disease Indication, Immunotherapy, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Vaccines

Autoantibodies as Anti-cancer Therapeutic Agents

TITLE: Autoantibodies as Anti-cancer Therapeutic AgentsCASE NUMBER: C13604UNMET NEED It has been speculated that autoimmunity and cancer were linked but the missing step was how to turn that concept into a robust method for identifying which specific auto antibodies would be generally effective. This problem was especially acute due...

Published: 6/20/2024 | Inventor(s): Andrew Ewald, Veena Padmanaban, Antony Rosen, Livia Casciola-Rosen

Keywords(s): Antibodies, Biologics, Breast Cancer, Cancers, Disease Indication, Immunotherapy, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Oncology