Search Results - autoimmune+diseases

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Profiling of Interferon signaling to diagnose autoimmune disorders

Unmet Need / Invention Novelty: Diagnosing an autoimmune disease using standard laboratory tests is challenging and often requires secondary validation due to high rates of false positives and overlapping biological signatures with other diseases. There is a critical need for an improved method to detect autoimmune disease signatures in tissue collected...

Published: 9/26/2024 | Inventor(s): Livia Casciola-Rosen, Antony Rosen, John Hall

Keywords(s): Autoimmune Diseases, Basic Research Biomarker, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Inflammatory Disorders, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Biomarkers, Clinical and Disease Specializations > Autoimmunity

Engineered Tolerogenic Artificial Antigen-presenting Cells for Specific Expansion of Regulatory T Cells

Unmet NeedGlobal incidence of autoimmune disease is on the rise, and currently one in twelve Americans (including one in 9 women) suffer from autoimmune disease. Particularly, Type 1 Diabetes (T1D) represents a highly prevalent autoimmune disease, affecting over 20 million people. These diseases occur when the body’s immune system incorrectly attacks...

Published: 9/27/2024 | Inventor(s): Jordan Green, Jamie Spangler, Stephany Tzeng, Kelly Rhodes, Giorgio Raimondi, Marcos Iglesias Lozano, Jakub Tomala, Derek VanDyke, Randall Meyer

Keywords(s): Autoimmune Diseases, Biologics, Discovery/Research Tools, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Cell Therapies

Cationic Biodegradable Polymer Compositions of Biomimetic Particles including Artificial Antigen Presenting Cells

Unmet NeedOver the past decade, a myriad of immune cell therapies based on the infusion of allogeneic immune cells into patients have been tested and progressed in clinical applications. Despite continual advances, immune cell therapy via antigen presenting cells is relatively expensive and time consuming, so biomimetic materials have been applied to...

Published: 9/26/2024 | Inventor(s): Jordan Green, Jonathan Schneck, Alyssa Kosmides Galaro, Randall Meyer, John Hickey, Kelly Rhodes

Keywords(s): Autoimmune Diseases, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics, Whole cell

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Autoimmunity

Neuritin Impact T Cell Tolerance Induction and Maintenance and is a Target for Tumor Immunotherapy

Unmet NeedCancer immunotherapy is a therapeutic approach that has revolutionized advanced cancer treatment. In particular, the use of therapeutic blocking antibodies to cytotoxic T-lymphocyte antigen 4 (CTLA4) and programmed cell death protein (PD-1) has achieved routine clinical use in numerous indications. Despite these promising results, monotherapy...

Published: 9/27/2024 | Inventor(s): Drew Pardoll, Hong Yu, Joseph Barbi, Fan Pan, Charles Drake

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Cancers, Combination, Disease Indication, Inflammatory Disorders, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

Screening Method to Identify Scleroderma Immune Responses with Anti-cancer Activity, and Induction of such Immune Responses for Cancer Therapy

Unmet NeedEpidemiological studies have shown that patients with scleroderma, a type of autoimmune rheumatic disease affecting the skin and connective tissues, have an increased risk of developing cancer relative to the general population. The exact etiology of scleroderma is still unknown. The Scleroderma Foundation estimates about 100,000 to 300,000...

Published: 9/26/2024 | Inventor(s): Ami Shah, Livia Casciola-Rosen, Antony Rosen, Takeru Igusa, Marikki Laiho

Keywords(s): Antibodies, Autoimmune Diseases, Biologics, Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Inflammatory Disorders, Risk Stratification, Scleroderma, Skin Disorders, Skin Fibrosis, Therapeutic Matter, Therapeutic Substance, Therapeutics

TC-1 P3 (A15)

Novelty:A cell line comprising the TC-1 P3 subclone to serve as an immune resistant tumor model for cancer immunotherapy research.Value Proposition:Many human tumors demonstrate downregulation of MHC class I molecule expression as a means of immune evasion. Thus, the development of a suitable tumor model with downregulated MHC class I expression is...

Published: 9/26/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Autoimmune Diseases, Basic Research Biomarker, Cancers, Cell Lines, Cloning Reagents, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Inflammatory Disorders, Mouse Cell Lines, Oncogene, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology

Inhibition of SGK-1 as a Novel Means to Treat Autoimmune Disease and Enhance Anti-pathogen and Anti-tumor Immunity

C11550: Novel Target for Treatment of Autoimmune DiseasesNovelty: Inhibition of this novel target has the potential to treat autoimmune diseases, as well as enhancing immunity against pathogen infections and tumor formation.Value Proposition: Currently, most immunosuppressive therapies non-specifically inhibit the immune system and leave the body susceptible...

Published: 9/26/2024 | Inventor(s): Emily Heikamp, Jonathan Powell

Keywords(s): Autoimmune Diseases, Biomarker, Cancers, Disease Indication, Immunotherapy, Inflammatory Disorders, Mechanism-of-action Biomarker, Single, Target, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Immunology

Methods, System, and Medium for Associating Rheumatoid Arthritis Subjects with Cardiovascular Disease

C11085: A Device Associating Rheumatoid Arthritis Subjects with Cardiovascular DiseaseNovelty: a computer implemented method for determining whether a rheumatoid arthritis patient is at risk for developing cardiovascular diseaseValue Proposition: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by progressive joint...

Published: 9/26/2024 | Inventor(s): Peter Alaupovic, Nicholas Knowlton, Adam Payne, Michael Centola, Joan Bathon, Jon Giles

Keywords(s): Arthritis, Assay, Autoimmune Diseases, Clinical Diagnostics, Computer and Network Systems, Computer Software, Diagnostic Tool, Disease Indication, In Vitro Diagnostics (Old), Inflammatory Disorders, Joint Disorders, Measurement Tool, Rheumatoid Arthritis

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Rheumatology > Arthritis, Clinical and Disease Specializations > Rheumatology > Rheumatoid Arthritis, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Clinical and Disease Specializations > Rheumatology, Clinical and Disease Specializations > Immunology

Manipulation of the Transcription Factor Helios to Enhance or Down-modulate Regulatory T Cell Function

C10323: Modulation of Regulatory T cell (Treg) Function Value Proposition: • Up-regulate immune response • Down-regulate immune response • Treatment of cancer, infection, autoimmunity, and inflammationTechnical Details: Regulatory T cells (Treg) are a subset of the CD4 T cell population that down-modulate an immune response. In some diseases, i.e....

Published: 9/26/2024 | Inventor(s): Jonathan Powell, Joseph Grosso, Edward Hipkiss, Drew Pardoll, Derese Getnet, Charles Drake

Keywords(s): Autoimmune Diseases, Biomarker, Cancers, Disease Indication, Inflammatory Disorders, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Inducing and Inhibiting T Cell Tolerance with A2a Receptor Agonists and Antagonists

C04897: Inducing and Inhibiting T Cell Tolerance with A2a Receptor Agonists and AntagonistsValue Proposition: • Therapeutic target for developing tolerance-inducing agents and tolerance-inhibiting agents for the treatment of autoimmune disease and cancer • Methods of treating an infection by enhancing the generation of antigen-specific...

Published: 9/26/2024 | Inventor(s): Paul Zarek, Charles Drake, Jonathan Powell

Keywords(s): Agonists/Promoters, Antagonists/Inhibitors, Autoimmune Diseases, Cancers, Disease Indication, Immunotherapy, Infectious Diseases, Inflammatory Disorders, Non-novel, Predicted Novelty, Repurposed, Single, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities