Search Results - randall+meyer

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Engineered Tolerogenic Artificial Antigen-presenting Cells for Specific Expansion of Regulatory T Cells

Unmet NeedGlobal incidence of autoimmune disease is on the rise, and currently one in twelve Americans (including one in 9 women) suffer from autoimmune disease. Particularly, Type 1 Diabetes (T1D) represents a highly prevalent autoimmune disease, affecting over 20 million people. These diseases occur when the body’s immune system incorrectly attacks...

Published: 9/27/2024 | Inventor(s): Jordan Green, Jamie Spangler, Stephany Tzeng, Kelly Rhodes, Giorgio Raimondi, Marcos Iglesias Lozano, Jakub Tomala, Derek VanDyke, Randall Meyer

Keywords(s): Autoimmune Diseases, Biologics, Discovery/Research Tools, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Diabetes > Type 1 Diabetes, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Cell Therapies

Tolerogenic Artificial Antigen-Presenting Cells

Unmet Need Autoimmune diseases are often treated with immunosuppressants that weaken the entire immune system, leaving patients vulnerable to infection. An ideal autoimmune therapy would establish immune tolerance to a specific self-antigen, while the rest of the immune system remains intact. One promising approach for regulating autoimmunity is via...

Published: 9/27/2024 | Inventor(s): Jordan Green, Kelly Rhodes, Randall Meyer, Stephany Tzeng

Keywords(s): Biologics, Drug Delivery Vehicle, Polymers, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations > Immunology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Cationic Biodegradable Polymer Compositions of Biomimetic Particles including Artificial Antigen Presenting Cells

Unmet NeedOver the past decade, a myriad of immune cell therapies based on the infusion of allogeneic immune cells into patients have been tested and progressed in clinical applications. Despite continual advances, immune cell therapy via antigen presenting cells is relatively expensive and time consuming, so biomimetic materials have been applied to...

Published: 9/26/2024 | Inventor(s): Jordan Green, Jonathan Schneck, Alyssa Kosmides Galaro, Randall Meyer, John Hickey, Kelly Rhodes

Keywords(s): Autoimmune Diseases, Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Inflammatory Disorders, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics, Whole cell

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Autoimmunity

Gene Delivery Particles to Induce Tumor-Derived Antigen Presenting Cells

Unmet Need Melanoma is an aggressive form of skin cancer that is characterized by high multidrug resistance and low survival rates. The median survival time for metastatic melanoma patients is approximately 8-9 months with a 3-year overall survival rate of less than 15%. As such, there is a compelling need for novel targeted melanoma therapies. Immunotherapy...

Published: 9/27/2024 | Inventor(s): Jordan Green, Stephany Tzeng, David Wilson, Randall Meyer

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Immunotherapies

Particulate Drug Delivery System to Enable Targeted Ultrasound-gated Release of Neuromodulatory Agents

Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Towards this goal, the JHU scientists have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug upon the application of focused ultrasound. These nanoparticles are composed of biodegradable...

Published: 9/26/2024 | Inventor(s): Jordan Green, Raag Airan, Randall Meyer

Keywords(s): CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Nerve Disorders and Injury, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices > Neurostimulation

Biomimetic Anisotropic Polymeric Particles with Naturally Derived Cell Membranes for Enhanced Drug Delivery

Unmet Need: Although biomimetic polymeric particles have been used for drug delivery, these particles have not been able to mimic the natural cell in terms of size, shape, mechanical properties, and surface features. This invention is a biomimetic particle platform that can be used to simulate natural cells found throughout the body. Technology Overview:...

Published: 9/26/2024 | Inventor(s): Jordan Green, Randall Meyer, Elana Ben-Akiva

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics, Vesicle

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Shape Memory Particles for Biomedical Uses

UNMET NEED Many diseases in the human body are best treated using drug delivery in which a triggered release of extracellular therapeutics or a triggered shape change of intracellular therapeutics mediates the delivery of drugs. However, these therapeutics should only be released under specific circumstances and locations to have the maximum impact...

Published: 9/26/2024 | Inventor(s): Jordan Green, Qiongyu Guo, Randall Meyer, Corey Bishop, Gregg Semenza, Anand Kumar

Keywords(s): Drug Delivery Vehicle, Polymers, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Biomimetic Artificial Cells: Anisotropic Supported Lipid Bilayers on Biodegradable Micro and Nanoparticles for Spatially Dynamic Surface Protein Presentation

Invention novelty: This invention is ellipsoidal biomimetic particle with supported lipid bilayer (SLB) that mimic the most critical features of cell-cell interactions including paracrine release of soluble mediators, dynamic radius of curvature, and fluidity of surface receptors for clustering. Value PropositionThere has been growing interest in the...

Published: 9/26/2024 | Inventor(s): Jordan Green, Randall Meyer, Mohit Mathew, Joel Sunshine, Ron Shmueli, Kevin Yarema

Keywords(s): Cancers, Discovery/Research Tools, Disease Indication, Drug Delivery Vehicle, Imaging and Sensing Systems, Imaging Modality, In Vitro Research Tool, In Vivo Medical Imaging, Infectious Diseases, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Diagnostic Imaging