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Polymeric particles for sustained delivery of multimodal peptide therapeutics

Polymeric particles for sustained delivery of multimodal peptide therapeutics JHU Ref #: C11250 Value Proposition · Stability: polymeric nanoparticle encapsulation increases and sustains peptide residence time, for increased accumulation in tissue vasculature and maximize treatment effects · Safety: use of nanoparticles...

Published: 10/27/2025 | Inventor(s): Jordan Green, Aleksander Popel, Joel Sunshine, Ron Shmueli, Stephany Tzeng, Kristen Kozielski

Keywords(s): Biologics, Drug Delivery Vehicle, Nucleic Acid, Peptide, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities

Cationic Polymers with Biphasic Biodegradation

Value Proposition· Delivery Efficacy: Demonstrates more effective gene delivery to cancer associated fibroblasts (CAFs) or human primary fibroblasts than industry gold-standards such as Lipofectamine 2000 and polyethylenimine (PEI).· Cargo Compatibility: Enables encapsulation and delivery of a wide range of cargos including, DNA, RNA,...

Published: 10/23/2025 | Inventor(s): Stephany Tzeng, Ron Shmueli, Nupura Bhise, Joel Sunshine, Jordan Green

Keywords(s): Drug Delivery Vehicle, Polymers, Therapeutic Matter, Therapeutics

Biomimetic Artificial Cells: Anisotropic Supported Lipid Bilayers on Biodegradable Micro and Nanoparticles for Spatially Dynamic Surface Protein Presentation

Invention novelty: This invention is ellipsoidal biomimetic particle with supported lipid bilayer (SLB) that mimic the most critical features of cell-cell interactions including paracrine release of soluble mediators, dynamic radius of curvature, and fluidity of surface receptors for clustering. Value PropositionThere has been growing interest in the...

Published: 10/23/2025 | Inventor(s): Jordan Green, Randall Meyer, Mohit Mathew, Joel Sunshine, Ron Shmueli, Kevin Yarema

Keywords(s): Cancers, Discovery/Research Tools, Disease Indication, Drug Delivery Vehicle, Imaging and Sensing Systems, Imaging Modality, In Vitro Research Tool, In Vivo Medical Imaging, Infectious Diseases, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Diagnostic Imaging

Artificial Cells of Defined and Dynamic Size and Shape

Invention novelty: This invention is polymer based artificial cells that can be functionalized to induce an immune response or act as stem cells. Value PropositionAntibiotics are the most commonly used treatment for infectious diseases. Unfortunately, overuse and misuse of these compounds is fairly common, and results in the development of antibiotic...

Published: 10/23/2025 | Inventor(s): Joel Sunshine, Karlo Perica, Jonathan Schneck, Jordan Green

Keywords(s): Cancers, Cell Signaling, Cell Therapy, Discovery/Research Tools, Disease Indication, Melanoma, Molecular Switches/Receptors, Research Reagent, Single, Skin Cancer, Therapeutic Matter, Therapeutics, Therapy Type, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Melanoma