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Polymeric particles for sustained delivery of multimodal peptide therapeutics

Polymeric particles for sustained delivery of multimodal peptide therapeutics JHU Ref #: C11250Value Proposition· Stability: polymeric nanoparticle encapsulation increases and sustains peptide residence time, for increased accumulation in tissue vasculature and maximize treatment effects· Safety: use of nanoparticles reduces toxicity by confining...

Published: 12/11/2025 | Inventor(s): Jordan Green, Aleksander Popel, Joel Sunshine, Ron Shmueli, Stephany Tzeng, Kristen Kozielski

Keywords(s): Biologics, Drug Delivery Vehicle, Nucleic Acid, Peptide, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities

Cationic Polymers with Biphasic Biodegradation

Value Proposition· Delivery Efficacy: Demonstrates more effective gene delivery to cancer associated fibroblasts (CAFs) or human primary fibroblasts than industry gold-standards such as Lipofectamine 2000 and polyethylenimine (PEI).· Cargo Compatibility: Enables encapsulation and delivery of a wide range of cargos including, DNA, RNA,...

Published: 12/11/2025 | Inventor(s): Stephany Tzeng, Ron Shmueli, Nupura Bhise, Joel Sunshine, Jordan Green

Keywords(s): Drug Delivery Vehicle, Polymers, Therapeutic Matter, Therapeutics

Biomimetic Artificial Cells: Anisotropic Supported Lipid Bilayers on Biodegradable Micro and Nanoparticles for Spatially Dynamic Surface Protein Presentation

Invention novelty: This invention is ellipsoidal biomimetic particle with supported lipid bilayer (SLB) that mimic the most critical features of cell-cell interactions including paracrine release of soluble mediators, dynamic radius of curvature, and fluidity of surface receptors for clustering. Value PropositionThere has been growing interest in the...

Published: 12/11/2025 | Inventor(s): Jordan Green, Randall Meyer, Mohit Mathew, Joel Sunshine, Ron Shmueli, Kevin Yarema

Keywords(s): Cancers, Discovery/Research Tools, Disease Indication, Drug Delivery Vehicle, Imaging and Sensing Systems, Imaging Modality, In Vitro Research Tool, In Vivo Medical Imaging, Infectious Diseases, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Diagnostic Imaging