Search Results - cell+therapy

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Bioreducible Poly(beta-amino ester)s for siRNA Delivery

C12218: Efficient Delivery Vehicle for Controlled Gene Knockdown Novelty: This technology comprises the use of bioreducible polymer based nanoparticle system that can release siRNA cargo to the cytoplasm of cells to knockdown target gene expression in tissues. Value Proposition: Gene therapy is a developing medical field and there is a need for...

Published: 9/26/2024 | Inventor(s): Kristen Kozielski, Stephany Tzeng, Jordan Green

Keywords(s): Biologics, Brain Cancer, Cancers, Cell Therapy, Disease Indication, Drug Delivery Vehicle, Glioma, Nucleic Acid, Polymers, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioma

Nanoparticle Modification of Human Adipose-derived Mesenchymal Stem Cells for Brain Cancer and Other Neurological Diseases

Human Adipose-derived Mesenchymal Stem Cells can be engineered to synthesize and release anti-tumor proteins and therefore can be used as “Trojan Horses”. The inventors have created a novel technology which encompasses a solution containing biodegradable, polymeric nanoparticles that is combined with Freshly-extracted Adipose Tissue (F.A.T.) (from...

Published: 9/26/2024 | Inventor(s): Jordan Green, Alfredo Quinones-Hinojosa

Keywords(s): Biologics, Brain Cancer, Cancers, Cell Therapy, CNS and Neurological Disorders, Disease Indication, Drug Delivery Vehicle, Glioma, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Glioma

Generation of PBMC-Originated, iPSC-Derived Corneal Endothelial Cells

Unmet NeedFuchs’ dystrophy, a progressive, hereditary disease of the cornea, is the leading cause of corneal transplants both in the US and worldwide. The disease results in the dysregulation and destruction of corneal endothelial cells which are responsible for keeping the eye properly hydrated. As the disease progresses, patients will experience blurred...

Published: 9/26/2024 | Inventor(s): Sheikh Amer Riazuddin, John Gottsch, Shahid Khan, Muhammad Ali

Keywords(s): Biologics, Cell Therapy, Corneal Dystrophy, Disease Indication, Eye Disorders, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell

Category(s): Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Research Tools > Research Stem Cells

Human Stem Cells and Monoclonal Antibodies (MY-10)

Human Stem Cells and Monoclonal Antibodies (MY-10) Case Number C02182 ABSTRACT Monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation. Cell suspensions containing...

Published: 9/26/2024 | Inventor(s): Curt Civin

Keywords(s): Antibodies, Biologics, Bone Marrow, Bone Marrow Transplant, Cell Therapy, Disease Indication, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Transplants

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Transplantation, Clinical and Disease Specializations > Transplantation > Bone Marrow Transplant

Generation of Adult Heart Muscle from Human Pluripotent Stem Cells

Unmet Need:Pluripotent stem cells (PSCs) are capable of becoming all types of patients’ body cells and thus, provide unprecedented opportunities for disease modeling and personalized medicine. With the capability, current cardiac regenerative medicine focuses on utilizing PSCs for modeling heart disease and cell-based interventions of cardiac repair....

Published: 9/26/2024 | Inventor(s): Chulan Kwon, Gunsik Cho

Keywords(s): Cardiovascular Diseases, Cell Model, Cell Therapy, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Single, Stem Cells, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities

Treatment of Acute Liver Injury and Hepatic Failure by Mobilization of Bone Marrow Derived Stem Cells

Acute Liver Failure (ALF), typically due to drug poisoning or viral hepatitis, accounts for around 10,000 deaths per year in the United States. Treatment options are severely limited: supportive observation in the hopes of spontaneous recovery or liver transplant. Liver transplant is an imperfect solution for these patients with extraordinary resource...

Published: 9/26/2024 | Inventor(s): Andrew Cameron

Keywords(s): Acute Liver Failure, Biologics, Cell Therapy, Disease Indication, Liver Disorders, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hepatology > Acute Liver Failure, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Hepatology, Technology Classifications > Therapeutic Modalities

Personalized, Allogeneic Cell Therapy of Cancer

The present invention describes methods of preparing a cell composition for treating cancer in a human being by obtaining lymphocytes from a partially or fully HLA-matched healthy donor, activating and expanding T cells reactive to tumor neoantigens (i.e. new epitopes resulting from somatic mutations in the cancer cell), and enriching for tumor-specific...

Published: 9/26/2024 | Inventor(s): Ephraim Fuchs, Howard Simons

Keywords(s): Biologics, Cancers, Cell Therapy, Disease Indication, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities

Implantable Bioreactor with a Non-Static Cell Pouch

UNMET NEED Heart failure after myocardial infarction (MI) is a common and morbid condition that affects millions worldwide. While there are multiple therapies that help the heart adapt and compensate for the damage incurred in an MI, there remains no method by which injured heart muscle may be repaired or replaced. Stem cell therapy shows great promise...

Published: 9/26/2024 | Inventor(s): Chao-Wei Hwang, Gary Gerstenblith, Peter Johnston, Robert Weiss, Gordon Tomaselli, Steven Schulman

Keywords(s): Cardiovascular Diseases, Cell Therapy, Disease Indication, Implanted Device, Implants, Myocardial Infarction (MI), Single, Therapeutic Devices, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Therapy Type, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Cardiovascular > Myocardial Infarction

Treatment of Injury or Neurodegenerative Disorders of the Enteric Nervous System (ENS) that cause Gastrointestinal Dysfunctions for which There is No Effective Therapy

JHU Ref. C13755Title: Preconditioned BMSC Promote de novo Nerve Regeneration: Potential application in therapy of enteric nerve injury/disorders and vascularized composite allotransplantation (VCA) UNMET NEEDInjury or neurodegenerative disorders of the enteric nervous system (ENS) cause gastrointestinal dysfunctions for which there is no effective therapy,...

Published: 9/26/2024 | Inventor(s): Xuhang Li, Xiaohua Hou, Rong Lin

Keywords(s): Cell Therapy, Disease Indication, Gastrointestinal Disorders, Single, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities

C12023: Autologous Adult Stem Cell Therapy for Prevention of Pre-Term Birth

Unmet NeedPreterm birth is among the top causes of death in infants worldwide. Preterm birth affects 12% of obstetrical outcomes and is associated with significant short term and long term public health ramifications for the children born in that setting. Currently, there are no effective therapies that significantly reduce uterine contractions to...

Published: 9/26/2024 | Inventor(s): Seyed Fatemi, Michael Johnston, Karin Blakemore, Irina Burd

Keywords(s): Biologics, Cell Therapy, Disease Indication, Inflammatory Disorders, Pregnancy, Preterm, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell, Womens Health, Women's Health

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Reproductive Health > Pregnancy, Clinical and Disease Specializations > Reproductive Health > Preterm, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Reproductive Health, Technology Classifications > Therapeutic Modalities

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