Search Results - gordon+tomaselli

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Cell Impregnated Nanofiber Stent Sleeve ("CINSS") for Intravascular Growth Factor Production

Invention novelty:Stem cells are harnessed to create a stent-based “paracrine factor factory” using a novel biodegradable nanofiber sleeve which protects the cells from washout and immune attack, and provides a sheltered in vivo on-stent milieu for the cells to continuously produce and deliver healing growth factors and exosomes to injured tissue.Value...

Published: 6/27/2024 | Inventor(s): Chao-Wei Hwang, Zhiyong Xia, Virginia Bogdan, Jeffrey Brinker, Gary Gerstenblith, Peter Johnston, Steven Schulman, Gordon Tomaselli, Robert Weiss

Keywords(s): Drug Delivery Vehicle, Hydrogel, Implanted Device, Implants, Stent, Therapeutic Devices, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

Implantable Bioreactor with a Non-Static Cell Pouch

UNMET NEED Heart failure after myocardial infarction (MI) is a common and morbid condition that affects millions worldwide. While there are multiple therapies that help the heart adapt and compensate for the damage incurred in an MI, there remains no method by which injured heart muscle may be repaired or replaced. Stem cell therapy shows great promise...

Published: 6/27/2024 | Inventor(s): Chao-Wei Hwang, Gary Gerstenblith, Peter Johnston, Robert Weiss, Gordon Tomaselli, Steven Schulman

Keywords(s): Cardiovascular Diseases, Cell Therapy, Disease Indication, Implanted Device, Implants, Myocardial Infarction (MI), Single, Therapeutic Devices, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Therapy Type, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Cardiovascular > Myocardial Infarction

Implantable Bioreactor for Delivery of Paracrine Factors

C11231 Implantable Bioreactor for Delivery of Paracrine FactorsBackground Intracoronary infusion and intra-myocardial injection of stem cells are believed to improve cardiac function after a heart attack by enhancing repair of damaged...

Published: 6/27/2024 | Inventor(s): Gary Gerstenblith, Chao-Wei Hwang, Peter Johnston, Gordon Tomaselli, Jeffrey Brinker, Robert Weiss, Jason Benkoski, George Coles, Steven Schulman

Keywords(s): Drug Delivery Device, Implanted Device, Implants, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices

Cardiac Entropy Based on Dynamic Nonlinear Comparison of Intervals of Ventricular Activation (RR) with Intervals of Ventricular Repolarization (QT)

C12025: Novel Method for Detection of Cardiac Rhythms Using Cardiac EntropyNovelty: This invention is a method for the analysis of heart rhythms based on entropy of electrocardiographic ventricular activation (RR) and repolarization (QT) for detecting risk of heart arrhythmia.Value Proposition: Despite several medical advancements, congestive heart...

Published: 6/27/2024 | Inventor(s): J. Moorman, Douglas Lake, Deeptankar DeMazumder, Gordon Tomaselli

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Measurement Tool

Category(s): Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics

Method to Improve Heart Failure by Restoration of Synchronous Contraction after Period of Dyssynchrony

C11275: Novel Method to Restore Synchronous Contraction in Heart FailureNovelty: This technology provides a pharmacological approach to mimic Cardiac Resynchronization Therapy (CRT) without artificial electric stimulation.Value Proposition: This invention provides potential improvement in heart failure patients whose hearts are synchronous or dyssynchronous....

Published: 6/27/2024 | Inventor(s): David Kass, Jonathan Kirk, Gordon Tomaselli

Keywords(s): Cardiovascular Diseases, Congestive Heart Failure, Congestive Heart Failure (CHF), Disease Indication, Electrical Stimulation Device, Implanted Device, Implants, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Congestive Heart Failure, Technology Classifications > Medical Devices > Therapeutic Devices, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Medical Devices