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Cell Impregnated Nanofiber Stent Sleeve ("CINSS") for Intravascular Growth Factor Production

Invention novelty:Stem cells are harnessed to create a stent-based “paracrine factor factory” using a novel biodegradable nanofiber sleeve which protects the cells from washout and immune attack, and provides a sheltered in vivo on-stent milieu for the cells to continuously produce and deliver healing growth factors and exosomes to injured tissue.Value...

Published: 3/13/2025 | Inventor(s): Chao-Wei Hwang, Zhiyong Xia, Virginia Bogdan, Jeffrey Brinker, Gary Gerstenblith, Peter Johnston, Steven Schulman, Gordon Tomaselli, Robert Weiss

Keywords(s): Drug Delivery Vehicle, Hydrogel, Implanted Device, Implants, Stent, Therapeutic Devices, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

Implantable Bioreactor for Delivery of Paracrine Factors

C11231 Implantable Bioreactor for Delivery of Paracrine FactorsBackground Intracoronary infusion and intra-myocardial injection of stem cells are believed to improve cardiac function after a heart attack by enhancing repair of damaged...

Published: 3/13/2025 | Inventor(s): Gary Gerstenblith, Chao-Wei Hwang, Peter Johnston, Gordon Tomaselli, Jeffrey Brinker, Robert Weiss, Jason Benkoski, George Coles, Steven Schulman

Keywords(s): Drug Delivery Device, Implanted Device, Implants, Therapeutic Devices, Therapeutics

Category(s): Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices